{"id":"W3110163884","doi":"10.1101/2020.11.29.20237875","title":"Clinical Trials in COVID-19 Management & Prevention: A Meta-epidemiological Study examining methodological quality","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Centre Hospitalier Universitaire de Sherbrooke; University of Ottawa; Western University; St. Michael's Hospital; Ted Rogers Centre for Heart Research; Impact; Toronto General Hospital; University Health Network; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Hamilton Health Sciences","keywords":"Medicine; Randomized controlled trial; Sample size determination; Blinding; Randomization; Clinical trial; Epidemiology; Consolidated Standards of Reporting Trials; Placebo; Internal medicine; Family medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":["metaresearch","metaepi_broad"],"domain":"methods","study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":["metaresearch","metaepi_broad"],"domain":"methods","study_design":"systematic_review","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"medium","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.1746198,0.003139256,0.02045033,0.01068529,0.001348477,0.008047948,0.004097037,0.004894467,0.005246653],"category_scores_gemma":[0.4015105,0.002194403,0.04626772,0.01357606,0.003008798,0.005080129,0.003660279,0.003586834,0.000387606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004984653,"about_ca_system_score_gemma":0.006235754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004047451,"about_ca_topic_score_gemma":0.00485819,"domain_scores_codex":[0.7231607,0.1750806,0.07239409,0.01258262,0.01494355,0.001838522],"domain_scores_gemma":[0.4565378,0.4455982,0.07005367,0.0138964,0.01232972,0.001584362],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"systematic_review","study_design_scores_codex":[0.003796828,0.00004817778,0.01650967,0.3272055,0.6372648,0.0001380353,0.0002669361,0.0007551679,0.00013825,0.0008317664,0.001129465,0.01191542],"study_design_scores_gemma":[0.003279898,0.0005490949,0.01206222,0.08499266,0.8908574,0.0002291666,0.0001904293,0.001131823,0.0002729228,0.002779835,0.003576094,0.00007840201],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0132853,0.9685357,0.009634572,0.001599348,0.0007857279,0.003671718,0.001487868,0.00010277,0.0008969983],"genre_scores_gemma":[0.653664,0.2748857,0.03347725,0.00539082,0.001250906,0.0279601,0.002277152,0.0002365837,0.0008574956],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9968607,"threshold_uncertainty_score":0.9234889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9534335328935374,"score_gpt":0.7343115340039995,"score_spread":0.2191219988895379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}