{"id":"W3110199593","doi":"10.1021/acschembio.0c00824","title":"Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products","year":2020,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"National Institute of General Medical Sciences; National Science Foundation","keywords":"Operon; Gene cluster; Streptomyces; Gene; Biology; Biosynthesis; Bacteria; Biochemistry; Structural motif; Genetics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000741815,0.0003339129,0.0001459056,0.0002565653,0.00009733448,0.0002896603,0.0001073278,0.0001573929,0.0009463144],"category_scores_gemma":[0.0001070374,0.00008622689,0.0002207518,0.000192979,0.000157396,0.0001848399,0.0002589757,0.0003028463,0.0003153617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176488,"about_ca_system_score_gemma":0.0002576777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003392948,"about_ca_topic_score_gemma":0.0003105883,"domain_scores_codex":[0.9999263,0.000009844054,0.000005252475,0.000024158,0.00001927036,0.000015135],"domain_scores_gemma":[0.9999123,0.00001021626,0.00002347361,0.000009852377,0.0000110676,0.00003305099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006222485,0.000009883576,0.000572333,0.00002463723,0.000001667742,0.00006477968,0.00001314822,0.00005608588,0.9964789,0.0001394524,0.00001618999,0.002560783],"study_design_scores_gemma":[0.00001598111,0.0003675393,0.01862717,0.00001092369,0.00002227004,0.0006622316,0.00007031535,0.001237575,0.9728473,0.0002871394,0.005843235,0.000008239695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917692,0.001473128,0.004242027,0.0001148041,0.00001901114,0.00002954606,0.0002977522,0.00008476669,0.001969743],"genre_scores_gemma":[0.9940159,0.0008290993,0.003716575,0.00004241809,0.00001050001,0.00001461937,0.0004007034,0.000009306135,0.0009607067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009463144,"threshold_uncertainty_score":0.003165722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800269632463731,"score_gpt":0.2492200805346895,"score_spread":0.2312173842100522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}