{"id":"W3110220548","doi":"10.1016/j.canlet.2020.11.030","title":"Alterations of circulating bacterial DNA in colorectal cancer and adenoma: A proof-of-concept study","year":2020,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario","funders":"National Natural Science Foundation of China","keywords":"Colorectal cancer; Metagenomics; Feces; Biology; Internal medicine; Gastroenterology; Microbiome; Adenoma; Gut flora; Cancer; Medicine; Microbiology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000345837,0.00007339674,0.0001448349,0.00001846846,0.00002284263,0.000005678503,0.00005721447,0.00003716879,0.00001976514],"category_scores_gemma":[0.00001445938,0.00007493484,0.00002256903,0.00007051697,0.00004473315,0.000003380208,0.00003762505,0.00005208508,8.44637e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001725016,"about_ca_system_score_gemma":0.0001051613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253773,"about_ca_topic_score_gemma":0.0004101298,"domain_scores_codex":[0.9994351,0.00003193828,0.0001885302,0.0001918548,0.00003969157,0.0001129087],"domain_scores_gemma":[0.999793,0.000005735,0.00008329149,0.00005606314,0.0000229415,0.00003896633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007533348,0.00003129131,0.04479665,0.00004680578,0.00002520557,0.000001538615,0.001986628,0.0001401754,0.9515356,0.000001178057,0.0003815957,0.0009779438],"study_design_scores_gemma":[0.001328003,0.0004075172,0.06447325,0.00003575235,0.00002058745,0.00000140165,0.0002241459,0.00005612105,0.932934,5.213921e-7,0.0004010747,0.0001176391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972456,0.0004377203,0.00005658749,0.001773386,0.00009684607,0.0003329086,0.00004628127,0.00000209155,0.000008575588],"genre_scores_gemma":[0.9987434,0.00001159908,0.00005733462,0.0009128122,0.0002027912,0.00004514939,0.00001647194,0.000008493211,0.000001960991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01967659,"threshold_uncertainty_score":0.3055754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772021299289345,"score_gpt":0.2781905493250099,"score_spread":0.2604703363321164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}