{"id":"W3110261743","doi":"10.1016/j.cell.2020.11.012","title":"Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Montreal Children's Hospital; Montreal Neurological Institute and Hospital; SickKids Foundation; Hospital for Sick Children; McGill University Health Centre; Jewish General Hospital; McGill University","funders":"National Center for Research Resources; National Cancer Institute; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Stand Up To Cancer; National Institutes of Health; Fondation Charles-Bruneau; Deutschen Konsortium für Translationale Krebsforschung; Bundesministerium für Bildung und Forschung; Royal Children's Hospital Foundation; Murdoch Children's Research Institute; Innovációs és Technológiai Minisztérium; Government of Ontario; Hospital for Sick Children; Genome British Columbia; Génome Québec; Deutsche Kinderkrebsstiftung; Wilhelm Sander-Stiftung; Univerzita Karlova v Praze; Ontario Research Foundation; V Foundation for Cancer Research; Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Prevention and Research Institute of Texas; Cancer Research Society; Brain Research UK; Genome Canada; Deutsches Zentrum für Neurodegenerative Erkrankungen; Government of Canada; University of Toronto; Alex's Lemonade Stand Foundation for Childhood Cancer; Pediatric Brain Tumor Foundation; Medical Research Council; Institut de recherche, Centre universitaire de santé McGill","keywords":"PDGFRA; Biology; Cancer research; Progenitor cell; OLIG2; Neurofibromin 1; Mutation; Cell biology; Genetics; Stem cell; Neuroscience; Neurofibromatosis; Oligodendrocyte; Stromal cell; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901753,0.0002697776,0.0001881857,0.0002746609,0.0002597896,0.0004045549,0.0003079888,0.0004335323,0.002396707],"category_scores_gemma":[0.0001037242,0.0001758401,0.0002165527,0.0002131284,0.0002801768,0.0002496816,0.0002856083,0.001117885,0.000604336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291615,"about_ca_system_score_gemma":0.0004442997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401814,"about_ca_topic_score_gemma":0.003984881,"domain_scores_codex":[0.9997503,0.0000205165,0.00001979484,0.00004087204,0.00009287333,0.00007566248],"domain_scores_gemma":[0.9998989,0.00001419554,0.00002270818,0.00001154746,0.00001095988,0.00004164872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235461,0.00003684154,0.000159876,0.00001141133,0.000004215065,0.00004013179,0.00001637994,0.00006886715,0.9978935,0.0002480259,0.0001222424,0.001274985],"study_design_scores_gemma":[0.00002630587,0.0001682318,0.001285953,0.000003123237,0.00001371578,0.0001680924,0.00004176884,0.0008202879,0.9947143,0.00005571211,0.002699334,0.00000302608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914233,0.0005617474,0.003055686,0.0002569992,0.0001162747,0.00003927421,0.0004171178,0.000149661,0.003979936],"genre_scores_gemma":[0.9896685,0.0002811586,0.003290469,0.00006503191,0.00001013964,0.00003241513,0.0002874898,0.00004144472,0.006323333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396707,"threshold_uncertainty_score":0.008017778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02908022026273449,"score_gpt":0.2959034009546637,"score_spread":0.2668231806919292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}