{"id":"W3110491319","doi":"10.1093/nar/gkaa966","title":"4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen <i>Leptospira interrogans</i>","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Leptospirosis research and findings","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Institut Pasteur; Agence Nationale de la Recherche; Pasteur Foundation","keywords":"Biology; Epigenetics; DNA methylation; Genetics; Methyltransferase; Gene; Mutant; Leptospira interrogans; Methylation; DNA methyltransferase; Virulence; Microbiology; Gene expression; Leptospira","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187342,0.0002543637,0.0002088913,0.0001341868,0.0001358374,0.0002782158,0.0001256078,0.0002550801,0.0005834937],"category_scores_gemma":[0.000141465,0.000113729,0.0001731625,0.00009008209,0.0002367447,0.000111993,0.0002180468,0.0002385206,0.00023599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001939267,"about_ca_system_score_gemma":0.0002010348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008882187,"about_ca_topic_score_gemma":0.001189177,"domain_scores_codex":[0.9998676,0.00002071976,0.000009883123,0.00003710152,0.00003698708,0.00002780328],"domain_scores_gemma":[0.9999037,0.00001136456,0.00004407052,0.00001025164,0.000014428,0.00001620201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004323801,0.000003947224,0.0006905281,0.0000189736,0.000002271058,0.00004287404,0.000009763346,0.00002116317,0.9982005,0.00003646294,0.0000114698,0.0009188405],"study_design_scores_gemma":[0.000007091121,0.0002586144,0.03691409,0.00001386663,0.00002725295,0.0006806934,0.0000993902,0.000598175,0.9584799,0.0001456066,0.002767465,0.000007713872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928201,0.002510075,0.003119341,0.0002001161,0.00001778233,0.00001461293,0.0002756805,0.00008159676,0.0009607954],"genre_scores_gemma":[0.9969338,0.0006888498,0.001212842,0.00005237453,0.000007648461,0.00001017688,0.0002798843,0.00001124228,0.0008032508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008882187,"threshold_uncertainty_score":0.001951993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09122583617380847,"score_gpt":0.3855277848344854,"score_spread":0.2943019486606769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}