{"id":"W3110491319","doi":"10.1093/nar/gkaa966","title":"4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen <i>Leptospira interrogans</i>","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Leptospirosis research and findings","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"European Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Institut Pasteur; Agence Nationale de la Recherche; Pasteur Foundation","keywords":"Biology; Epigenetics; DNA methylation; Genetics; Methyltransferase; Gene; Mutant; Leptospira interrogans; Methylation; DNA methyltransferase; Virulence; Microbiology; Gene expression; Leptospira","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474163,0.0001483599,0.0002070096,0.00009591545,0.00051691,0.0001133145,0.0006061207,0.0002580806,0.0002224965],"category_scores_gemma":[0.001065699,0.0001166544,0.00006642794,0.0005459026,0.0008421658,0.0001598438,0.0002152426,0.0005815853,0.0001825274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009212569,"about_ca_system_score_gemma":0.00006481483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005109527,"about_ca_topic_score_gemma":0.00001328391,"domain_scores_codex":[0.9976547,0.0005813629,0.0003178465,0.0005340872,0.0002223231,0.0006896795],"domain_scores_gemma":[0.9989025,0.0004306866,0.00003634443,0.0003173386,0.0002334782,0.00007967213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056205,0.0001177919,0.005700476,0.0000788365,0.00001835294,0.000002775577,0.00270658,5.448765e-7,0.9608868,0.01309372,0.005869452,0.01131907],"study_design_scores_gemma":[0.008144469,0.006350141,0.3456998,0.0002255593,0.00006987443,0.00005934995,0.00867069,0.001587362,0.3690626,0.03563697,0.2234496,0.001043602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610615,0.001213646,0.002553157,0.03196934,0.00005078076,0.001462928,0.0002299111,0.00004311466,0.001415659],"genre_scores_gemma":[0.9980417,0.00008126709,0.0002033053,0.001188503,0.00006982907,0.0001981061,0.000104984,0.00001651319,0.00009576374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5918242,"threshold_uncertainty_score":0.4757029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09122583617380847,"score_gpt":0.3855277848344854,"score_spread":0.2943019486606769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}