{"id":"W3110516422","doi":"10.1158/2643-3249.lymphoma20-po-42","title":"Abstract PO-42: TBL1XR1 mutations drive extranodal lymphomagenesis by inducing a protumorigenic memory B-cell fate","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of Toronto","funders":"","keywords":"Germinal center; BCL6; Biology; Transcription factor; Cancer research; Phenotype; Cell fate determination; Lymphoma; Reprogramming; B cell; Immune system; Cell; Gene; Immunology; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009780863,0.0003064054,0.000173228,0.0002397717,0.0001739822,0.0004047513,0.0002317454,0.0003271221,0.007924083],"category_scores_gemma":[0.00007302788,0.0001613534,0.0001744227,0.0001204045,0.0003017566,0.0001643261,0.0003059437,0.0006265189,0.001759037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195339,"about_ca_system_score_gemma":0.000167937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890542,"about_ca_topic_score_gemma":0.0006829394,"domain_scores_codex":[0.9998491,0.00002176476,0.00001638603,0.0000381377,0.0000451892,0.00002954446],"domain_scores_gemma":[0.9999146,0.0000115862,0.00002448718,0.00001304059,0.000006489101,0.00002988504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005408533,0.00001489814,0.0001982788,0.00002142535,0.000002661754,0.000129865,0.00001296394,0.00004298456,0.9981276,0.0001805311,0.00014443,0.0010703],"study_design_scores_gemma":[0.00003018576,0.0002295193,0.005045376,0.000007377653,0.00001182784,0.001309755,0.0000571523,0.000566643,0.9848156,0.0001194326,0.007801617,0.000005448164],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862559,0.0008482364,0.003701332,0.0003396197,0.0001201113,0.00004131181,0.0009626464,0.0006136912,0.00711698],"genre_scores_gemma":[0.9794849,0.0005256308,0.001795058,0.0001070406,0.00002034981,0.00003117556,0.0007419072,0.0001081855,0.01718585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007924083,"threshold_uncertainty_score":0.02650869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507749552767352,"score_gpt":0.2904823327413624,"score_spread":0.2654048372136889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}