{"id":"W3110565071","doi":"10.1523/eneuro.0255-20.2020","title":"Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia","year":2020,"lang":"en","type":"review","venue":"eNeuro","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Baycrest Hospital; University of Toronto; SickKids Foundation; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Centre for Addiction and Mental Health Foundation","keywords":"Biology; Microglia; Neuroscience; Entorhinal cortex; Human brain; Transcriptome; Neurodegeneration; Ribosomal protein; Middle temporal gyrus; Neurofibrillary tangle; Gene; Gene expression; Alzheimer's disease; Hippocampus; Pathology; Senile plaques; Genetics; Ribosome; Disease; Medicine; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001653453,0.000392731,0.001052323,0.0009666801,0.0003345888,0.0007586891,0.0003240275,0.0003153239,0.001513193],"category_scores_gemma":[0.001449476,0.0001829584,0.001366813,0.001139865,0.0003252674,0.0003320698,0.0004272631,0.0004028161,0.0001776923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749924,"about_ca_system_score_gemma":0.0002466753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009088023,"about_ca_topic_score_gemma":0.001712298,"domain_scores_codex":[0.9990669,0.0002410265,0.00007214864,0.0004005699,0.0001227163,0.00009671353],"domain_scores_gemma":[0.9989047,0.0003379247,0.000324012,0.0002222632,0.0001268982,0.00008408973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007034815,0.0001079389,0.7380081,0.001641126,0.01574204,0.0009536794,0.0004963624,0.0005675415,0.2003138,0.0006879181,0.001175764,0.03327091],"study_design_scores_gemma":[0.00005398189,0.0005038456,0.9748124,0.00008683962,0.006876712,0.001775196,0.000325952,0.001012628,0.01069756,0.001120814,0.002707888,0.00002619661],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9835808,0.00889335,0.003200789,0.0001604452,0.00004453958,0.00002084186,0.003408136,0.00005271097,0.0006383879],"genre_scores_gemma":[0.99611,0.000920915,0.001014497,0.0001043804,0.00002036925,0.00002570903,0.001489549,0.00003576163,0.000278841],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001653453,"threshold_uncertainty_score":0.008744359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0462738940429113,"score_gpt":0.311848957435873,"score_spread":0.2655750633929617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}