{"id":"W3110571360","doi":"10.1101/2020.11.25.396069","title":"Environment-driven reprogramming of gamete DNA methylation occurs during maturation and is transmitted intergenerationally in salmon","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; Atlantic Canada Opportunities Agency; Mitacs","keywords":"Reprogramming; DNA methylation; Epigenetics; Gamete; Context (archaeology); Epigenome; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289791,0.00009039135,0.0001102351,0.000143106,0.0001263767,0.0001734813,0.0001173497,0.0001553866,0.001533803],"category_scores_gemma":[0.0001602123,0.0001195265,0.0001140723,0.00008656863,0.0001612416,0.0001070045,0.0003465657,0.0002623128,0.0002843384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772673,"about_ca_system_score_gemma":0.000148898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700184,"about_ca_topic_score_gemma":0.003467753,"domain_scores_codex":[0.9999429,0.000006320019,0.000003364664,0.00002368061,0.00001174429,0.00001199423],"domain_scores_gemma":[0.9999002,0.00001692353,0.00003085405,0.00001755558,0.00001681903,0.00001766956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005151398,0.000007532993,0.009298529,0.00001424552,0.00000732626,0.00003836691,0.00006341684,0.00005488735,0.9877908,0.00007321298,0.00005053934,0.002549694],"study_design_scores_gemma":[0.00001233944,0.0002956722,0.7303453,0.0000121446,0.00002816129,0.0003183941,0.0002344934,0.001068693,0.2652596,0.0002749119,0.002134807,0.00001552869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977118,0.000162929,0.001198694,0.00002899101,0.000006053594,0.000003534308,0.0002639142,0.00002280627,0.0006013658],"genre_scores_gemma":[0.9976094,0.00008721964,0.0004077981,0.00002721684,0.000002134373,0.000006947541,0.0002762579,0.00001447638,0.00156866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700184,"threshold_uncertainty_score":0.005131066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169146360277472,"score_gpt":0.2199692976220166,"score_spread":0.2082778340192419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}