{"id":"W3110615492","doi":"10.1101/2020.12.03.409128","title":"Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Utah; National Center for Research Resources; American Diabetes Association; American Heart Association; U.S. Department of Agriculture; National Cancer Institute; National Institutes of Health","keywords":"Sphingolipid; Cancer research; Biology; Stem cell; Progenitor cell; Peroxisome; Cell biology; Endocrinology; Internal medicine; Downregulation and upregulation; Colorectal cancer; Cancer; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099749,0.0002023034,0.0001446007,0.0002405548,0.0001532333,0.0003923024,0.0001197379,0.0001843931,0.002630101],"category_scores_gemma":[0.000122442,0.0001227738,0.0001191256,0.0001688481,0.0001867053,0.000146264,0.0003159645,0.000335581,0.0009848821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003340218,"about_ca_system_score_gemma":0.0002186649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000705684,"about_ca_topic_score_gemma":0.0008702331,"domain_scores_codex":[0.9999446,0.0000061255,0.000003751979,0.00001622995,0.00001815523,0.00001131572],"domain_scores_gemma":[0.9999342,0.00001061522,0.00001475067,0.00001015035,0.00001007299,0.0000200686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001490536,0.000008276243,0.0008418915,0.00004139712,0.000006059072,0.0001113636,0.00001595939,0.0001757034,0.9936027,0.001050301,0.000381718,0.003615625],"study_design_scores_gemma":[0.00002979533,0.00006748061,0.009324366,0.000009326478,0.00001001321,0.0004124702,0.00003797066,0.001895819,0.9757522,0.001404881,0.01104952,0.000006145214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718075,0.005852012,0.008556118,0.0009295003,0.0002121028,0.00002023755,0.001721269,0.0003969813,0.01050431],"genre_scores_gemma":[0.9809613,0.001967761,0.003134192,0.00008153234,0.00004025783,0.00001337167,0.001720495,0.0000861789,0.01199494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002630101,"threshold_uncertainty_score":0.008798599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240924966118541,"score_gpt":0.2241017285173354,"score_spread":0.21169247885615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}