{"id":"W3110635404","doi":"10.3389/fnagi.2020.550664","title":"Distinct Brain Functional Impairment Patterns Between Suspected Non-Alzheimer Disease Pathophysiology and Alzheimer’s Disease: A Study Combining Static and Dynamic Functional Magnetic Resonance Imaging","year":2020,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; Johnson and Johnson Pharmaceutical Research and Development; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Superior frontal gyrus; Precuneus; Alzheimer's disease; Neurodegeneration; Neuroscience; Pathophysiology; Psychology; Insula; Medicine; Medial frontal gyrus; Cognitive decline; Snap; Population; Functional magnetic resonance imaging; Disease; Internal medicine; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006383768,0.0005258447,0.000434697,0.00110862,0.0004704029,0.0004921371,0.0002481113,0.0006212036,0.0009118763],"category_scores_gemma":[0.00123133,0.0002741529,0.0003809315,0.0005932655,0.0004785834,0.0005656907,0.0005100515,0.0002882042,0.000195645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436404,"about_ca_system_score_gemma":0.0002100397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001702159,"about_ca_topic_score_gemma":0.002873176,"domain_scores_codex":[0.9997112,0.00005406033,0.00003895829,0.0001149216,0.00003736987,0.00004343013],"domain_scores_gemma":[0.9993821,0.0001354688,0.000179458,0.00006011805,0.00009345197,0.0001494505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000692128,0.0001181673,0.9957789,0.00001381079,0.000120762,0.000341714,0.0001686132,0.00003072248,0.001287341,0.00001237542,0.00002710908,0.001408445],"study_design_scores_gemma":[0.00001309624,0.0002902395,0.9985828,0.000002809682,0.00003706208,0.000670479,0.0001449028,0.0001052882,0.00007693214,0.00002042005,0.00005269518,0.00000314071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997587,0.00006262578,0.00004504791,0.000003422095,0.000001294493,0.000005363427,0.00003096372,7.767503e-7,0.00009171526],"genre_scores_gemma":[0.9997115,0.00002990534,0.00007322837,0.000007040635,0.000005644941,0.000007214022,0.0001166647,7.883599e-7,0.00004811566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702159,"threshold_uncertainty_score":0.003384471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02973379683380444,"score_gpt":0.262820412604456,"score_spread":0.2330866157706516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}