{"id":"W3110677243","doi":"10.1002/slct.202003893","title":"Influence of C5‐Substituents on Repair of O 4 ‐Methyl Adducts of Pyrimidines by O 6 ‐Alkylguanine DNA Alkyltransferases","year":2020,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Trifluoromethyl; Adduct; DNA; Chemistry; Halogen; Alkylation; Stereochemistry; Nucleobase; DNA repair; Deoxyguanosine; Thymidine; Medicinal chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001875494,0.00056017,0.0007982385,0.00003555811,0.0000625303,0.00001041265,0.0007750294,0.0004712349,0.0001281529],"category_scores_gemma":[0.0007060967,0.000571802,0.0004222723,0.0004092997,0.0004770056,0.00001700975,0.0001573707,0.0003048171,0.000008224499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002445319,"about_ca_system_score_gemma":0.000230758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003026825,"about_ca_topic_score_gemma":6.977048e-7,"domain_scores_codex":[0.9969919,0.00005097765,0.0009664823,0.0009079099,0.0005217174,0.0005610251],"domain_scores_gemma":[0.9979122,0.00007370196,0.0003974189,0.0008610812,0.0004172132,0.0003384309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005824055,0.0003707949,0.003413826,0.001098778,0.0002794527,0.000007989842,0.00018346,0.003622339,0.9749213,0.000004773192,0.01532968,0.0001851915],"study_design_scores_gemma":[0.001352279,0.0005870537,0.00008619633,0.0001707046,0.000132411,0.00001808745,0.0001197358,0.0002404144,0.9896784,0.000007935093,0.007134794,0.0004719226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955543,0.001442402,0.00002937068,0.0001194388,0.00001654022,0.0002145866,0.0005737637,0.00005309097,0.001996479],"genre_scores_gemma":[0.9974964,0.0006138549,0.0002503256,0.0004404739,0.0002115417,0.00002258968,0.0005575902,0.00007623731,0.0003310299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01475716,"threshold_uncertainty_score":0.9996734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007936069888716238,"score_gpt":0.2171474424296639,"score_spread":0.2092113725409477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}