{"id":"W3110716355","doi":"10.1523/jneurosci.1865-20.2020","title":"Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease","year":2020,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pacific Centre for Reproductive Medicine; BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; National Research Foundation; BC Children's Hospital; Michael Smith Health Research BC; National Research Foundation of Korea; CHDI Foundation","keywords":"Huntingtin; Neurodegeneration; Huntington's disease; Huntingtin Protein; Neuroscience; Biology; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464727,0.0003509847,0.0004236801,0.0002787396,0.0001264458,0.0003757227,0.0002825629,0.0005770145,0.0007616291],"category_scores_gemma":[0.0001955048,0.0001161526,0.0002369475,0.00009968477,0.0003008695,0.0004201413,0.0002032279,0.0006072283,0.0002827448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457614,"about_ca_system_score_gemma":0.0002116198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002830658,"about_ca_topic_score_gemma":0.0003987472,"domain_scores_codex":[0.9998662,0.00001281487,0.00001762493,0.0000319591,0.0000539886,0.00001727435],"domain_scores_gemma":[0.9998456,0.0000134502,0.00005820634,0.00001447785,0.00003140676,0.00003694912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005305635,0.00005948297,0.001386925,0.0001721261,0.00004346474,0.0003940251,0.00004724186,0.00003451469,0.9898303,0.0001966186,0.000157101,0.007147676],"study_design_scores_gemma":[0.0001344389,0.003290321,0.06896609,0.00009668781,0.0002138833,0.005158985,0.00009620675,0.0007759506,0.9118391,0.001027851,0.008374162,0.00002622344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980701,0.01199779,0.005128148,0.0002858792,0.00006783793,0.00005268928,0.0005363184,0.0001909433,0.001039399],"genre_scores_gemma":[0.9914341,0.003912794,0.001405061,0.0002163963,0.00004356142,0.00005293646,0.0006003034,0.00003164579,0.002303174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007616291,"threshold_uncertainty_score":0.00254792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03812352677958986,"score_gpt":0.2722666301022349,"score_spread":0.234143103322645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}