{"id":"W3110751566","doi":"10.1111/1440-1681.13443","title":"Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo","year":2020,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology and Physiology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"AMPK; Osteoblast; Chemistry; Alkaline phosphatase; Cell biology; Adipogenesis; In vivo; Phosphorylation; Protein kinase A; In vitro; Signal transduction; Zebrafish; Biochemistry; Biology; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007008878,0.0001416432,0.0002720942,0.00002699751,0.00004664248,0.00000708107,0.00004795151,0.0001691368,0.00005324909],"category_scores_gemma":[0.00003064787,0.0001314718,0.00003574071,0.00004758968,0.0003261774,0.00001217789,0.0001609023,0.000114164,0.000002084722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002393456,"about_ca_system_score_gemma":0.00001269378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002887262,"about_ca_topic_score_gemma":0.000007152481,"domain_scores_codex":[0.9989488,0.0001663221,0.0002763072,0.000414605,0.00002874027,0.0001652621],"domain_scores_gemma":[0.9996885,0.00006250852,0.0000575977,0.0000517433,0.00001009946,0.0001295666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003356184,0.0002901979,0.02083985,0.00001928049,0.00001879267,0.000003521238,0.00005927921,0.0000127778,0.974262,0.000008366291,0.0001489334,0.0009808126],"study_design_scores_gemma":[0.004977217,0.0005292553,0.2226672,0.000004898429,0.00003218696,0.000004813754,0.0001265405,0.002310689,0.7677952,0.0001570249,0.001159883,0.0002351303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922748,0.007149692,0.0000121173,0.0002000181,0.0001385072,0.0001723376,0.00001899149,0.00000706259,0.00002651833],"genre_scores_gemma":[0.9958664,0.0008767284,0.00002740036,0.002814306,0.0003040559,0.00003581843,0.00005983634,0.000008299275,0.000007146227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2064668,"threshold_uncertainty_score":0.5361264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491038690769161,"score_gpt":0.3086282070401367,"score_spread":0.2937178201324451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}