{"id":"W3110770353","doi":"10.1093/neuonc/noaa222.374","title":"IMMU-18. FAVORABLE OUTCOME IN REPLICATION REPAIR DEFICIENT HYPERMUTANT BRAIN TUMORS TO IMMUNE CHECKPOINT INHIBITION: AN INTERNATIONAL RRD CONSORTIUM REGISTRY STUDY","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; CancerCare Manitoba; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Medicine; Immune system; Oncology; Internal medicine; Immunotherapy; Brain tumor; Immune checkpoint; Cancer research; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001132115,0.0003764808,0.0004578415,0.0009525402,0.0006819103,0.001064661,0.0005728102,0.0003454674,0.001576288],"category_scores_gemma":[0.0021923,0.0002660821,0.0003847063,0.001424963,0.0003287228,0.0004933839,0.0008648863,0.0004739223,0.0006484844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427181,"about_ca_system_score_gemma":0.0007257468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004008932,"about_ca_topic_score_gemma":0.004818338,"domain_scores_codex":[0.9990799,0.0002442498,0.00007782903,0.0003252391,0.0001404957,0.0001322262],"domain_scores_gemma":[0.9975024,0.0002069462,0.0009579103,0.0005699209,0.000277917,0.0004849345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002453447,0.0000541623,0.9970214,0.000009599673,0.00006029215,0.0003788575,0.00009293153,0.00005084216,0.0004210474,0.00003142081,0.0004346901,0.001199471],"study_design_scores_gemma":[0.0000619862,0.0003270869,0.9942858,0.00001048555,0.0001094749,0.002880496,0.000437447,0.0003730607,0.0006457094,0.00004476615,0.0008092644,0.000014418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971799,0.00007128255,0.0001173168,0.00003098294,0.000002946686,0.00002467228,0.002012849,0.00001256223,0.0005473793],"genre_scores_gemma":[0.9964035,0.00005807924,0.0001276631,0.00002914298,0.00000605274,0.0000377789,0.00319911,0.00001095817,0.0001276683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004008932,"threshold_uncertainty_score":0.007971168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05623190931796352,"score_gpt":0.3499459876646465,"score_spread":0.293714078346683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}