{"id":"W3110808061","doi":"10.1002/alz.041530","title":"Neuronal expression of a single‐chain variable fragment antibody against Aβ oligomers protects synapses and rescues memory in Alzheimer models","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Robarts Clinical Trials; Western University","funders":"","keywords":"Hippocampal formation; Long-term potentiation; Neuroscience; Antibody; In vivo; Inhibitory postsynaptic potential; Transduction (biophysics); Amyloid (mycology); Chemistry; Cell biology; Biology; Immunology; Biochemistry; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120982,0.000445197,0.0003434388,0.0003095876,0.0001639916,0.0002401448,0.0003874417,0.0004193546,0.001015658],"category_scores_gemma":[0.00007156832,0.0001274239,0.0003783537,0.000176156,0.0001843458,0.0002000447,0.0001267414,0.0008516321,0.0003647841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696915,"about_ca_system_score_gemma":0.0002529228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008514236,"about_ca_topic_score_gemma":0.0007729561,"domain_scores_codex":[0.9999118,0.00000601993,0.0000111343,0.00002094074,0.00002222107,0.00002799972],"domain_scores_gemma":[0.9999273,0.000005567638,0.00001640883,0.000009156279,0.00001878001,0.00002276184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021294,0.00008579712,0.00007086743,0.0000424208,0.000008626203,0.00001892441,0.000008718917,0.00003364561,0.998589,0.00004570717,0.00005511219,0.0009390876],"study_design_scores_gemma":[0.00002975389,0.0007636778,0.002137014,0.00001136942,0.00004215146,0.0001434435,0.00002021487,0.0006279734,0.9948913,0.00004700626,0.001282724,0.00000339854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934284,0.00197249,0.002698049,0.00009663888,0.00005282794,0.00003433491,0.000473443,0.0001520052,0.001091879],"genre_scores_gemma":[0.9911906,0.001814393,0.002198514,0.00006196112,0.00001944616,0.00007093696,0.0009494614,0.00002312474,0.003671562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015658,"threshold_uncertainty_score":0.003397703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04515134819551912,"score_gpt":0.2940117040511506,"score_spread":0.2488603558556315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}