{"id":"W3110809437","doi":"10.1139/bcb-2020-0279","title":"Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1","year":2020,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pyroptosis; Melatonin; Cell biology; Oxidative stress; Endothelial stem cell; Biology; Programmed cell death; Endocrinology; Internal medicine; Chemistry; Apoptosis; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129763,0.000187541,0.0002317156,0.0001794967,0.0001448842,0.0001528948,0.0001192086,0.0001515898,0.0007041869],"category_scores_gemma":[0.0001292433,0.00006506532,0.0002046932,0.0001020436,0.0001353939,0.0001293261,0.0001146294,0.000347847,0.00008972528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713108,"about_ca_system_score_gemma":0.0001978753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007819958,"about_ca_topic_score_gemma":0.001417258,"domain_scores_codex":[0.9999284,0.00001597692,0.000009899836,0.00001259719,0.00001389451,0.00001918158],"domain_scores_gemma":[0.9999431,0.000005365267,0.00002324863,0.000006593113,0.00001003771,0.00001166439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005219182,0.00008922342,0.0003976697,0.0001249213,0.00001664247,0.00004698221,0.0000263283,0.00006020927,0.9931065,0.0001010711,0.0001190052,0.005389404],"study_design_scores_gemma":[0.000203165,0.002497782,0.0259642,0.00002669192,0.00009360194,0.0002577914,0.00008637846,0.001437682,0.9617817,0.0001908824,0.007448335,0.00001183065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863501,0.00871956,0.002880005,0.0002437601,0.0001014254,0.00003937778,0.0001821588,0.0001349444,0.001348596],"genre_scores_gemma":[0.9959797,0.001658505,0.001035142,0.00007802442,0.00002010312,0.00002588465,0.00009911726,0.000007635715,0.001095997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007819958,"threshold_uncertainty_score":0.002355754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003530180238463141,"score_gpt":0.1790636313906035,"score_spread":0.1755334511521404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}