{"id":"W3110835254","doi":"10.1016/j.bbamcr.2020.118928","title":"Cathepsin B is an executioner of ferroptosis","year":2020,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Wings for Life","keywords":"Cathepsin B; GPX4; Programmed cell death; Cell biology; Cathepsin; Biology; Cathepsin D; Chromatin; Trichostatin A; Glutathione; Apoptosis; Histone; Biochemistry; Glutathione peroxidase; Histone deacetylase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004845699,0.0003398628,0.0005918759,0.0002662711,0.0001511504,0.00008039323,0.0005720218,0.0002296071,0.0003262478],"category_scores_gemma":[0.00008797654,0.0003035316,0.0003870026,0.001389657,0.0004437086,0.0001392386,0.0003208266,0.0007560525,0.0001418343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009651324,"about_ca_system_score_gemma":0.0004835083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992324,"about_ca_topic_score_gemma":0.000001411126,"domain_scores_codex":[0.9958887,0.0004263358,0.000484358,0.0009305165,0.001540887,0.0007292284],"domain_scores_gemma":[0.9975395,0.00006526502,0.000140032,0.0009601777,0.0006001286,0.0006948733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004948297,0.0009130987,0.00003075733,0.0003137659,0.0001263099,0.00002551467,0.002084923,0.000001615205,0.9892717,0.0002093485,0.005740391,0.0007877417],"study_design_scores_gemma":[0.001039766,0.002012863,0.0009841686,0.0000905058,0.0001272577,0.000002618679,0.0005190638,0.0005154983,0.9915314,0.00006304651,0.002818113,0.0002957078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727432,0.0003245932,0.00009128137,0.02035951,0.00004023777,0.0007580803,0.00007206461,0.00007621622,0.005534831],"genre_scores_gemma":[0.9948444,0.0004922579,0.001100669,0.002869093,0.0001661435,0.00009039939,0.0001069578,0.0001038052,0.0002262459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02210124,"threshold_uncertainty_score":0.9999417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1033655077669789,"score_gpt":0.369786910848224,"score_spread":0.2664214030812451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}