{"id":"W3110859485","doi":"10.1093/neuonc/noaa215.897","title":"TAMI-08. A TALE OF TWO TELOMERE MAINTENANCE MECHANISMS: TERT EXPRESSION AND THE ALT PATHWAY INDUCE UNIQUE MRS-DETECTABLE METABOLIC REPROGRAMMING IN LOW-GRADE GLIOMAS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Telomere; Biology; Cancer research; Glutaminase; Alanine; Enzyme; Glutamine; Cell biology; Biochemistry; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349146,0.0003451275,0.0003074492,0.0001558884,0.000141439,0.0003385152,0.0002400201,0.0004005601,0.003314071],"category_scores_gemma":[0.0001337511,0.000150659,0.0003426194,0.0001321682,0.0002038948,0.0002312924,0.0002300996,0.0008461831,0.0008302412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805807,"about_ca_system_score_gemma":0.0002429575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000287378,"about_ca_topic_score_gemma":0.0004585805,"domain_scores_codex":[0.9998915,0.00001340012,0.000008165121,0.0000246653,0.00002080766,0.00004126909],"domain_scores_gemma":[0.9999083,0.000009284128,0.00002322415,0.00001140598,0.000009208251,0.0000385489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000526534,0.00008861817,0.0002218859,0.00007933202,0.00001723536,0.0001367481,0.00002321592,0.0000359203,0.9940954,0.00027927,0.0003763058,0.004119544],"study_design_scores_gemma":[0.0001089023,0.002091419,0.003634219,0.00001568086,0.00006894796,0.000773533,0.00008269164,0.0008118026,0.9805409,0.0002458193,0.01161432,0.00001170383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862155,0.001884638,0.005112913,0.0006171919,0.0003195718,0.00009848599,0.0008233605,0.0004569021,0.004471471],"genre_scores_gemma":[0.985076,0.0009877403,0.003997679,0.0003922143,0.00002857121,0.0001290902,0.001250997,0.000114648,0.008023031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003314071,"threshold_uncertainty_score":0.0110867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01524325212504395,"score_gpt":0.2864258164013784,"score_spread":0.2711825642763344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}