{"id":"W3110887690","doi":"10.1093/neuonc/noaa222.659","title":"PATH-24. MOLECULAR CLASSIFICATION OF HIGH RISK INFANT EMBRYONAL BRAIN TUMORS ENROLLED IN THE ACNS0334 TRIAL: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Brain tumor; CDKN2A; Atypical teratoid rhabdoid tumor; Germline; PTCH1; Oncology; Internal medicine; Glioma; Astrocytoma; Medicine; Biology; Cancer research; Pathology; Bioinformatics; Cancer; Sonic hedgehog; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002714632,0.0004060878,0.0009588109,0.000234798,0.0002620076,0.001138259,0.0003768782,0.0004953083,0.001973462],"category_scores_gemma":[0.002220587,0.0001711107,0.0009320563,0.0004520607,0.0003386296,0.000525055,0.0003019468,0.001214724,0.0003001255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007082272,"about_ca_system_score_gemma":0.00108543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116723,"about_ca_topic_score_gemma":0.003705607,"domain_scores_codex":[0.9990336,0.0004744849,0.00006581203,0.0001858736,0.0001404476,0.00009976966],"domain_scores_gemma":[0.9988773,0.0003214066,0.0003107963,0.0001456403,0.00008953946,0.0002552742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4825028,0.003051651,0.2900466,0.001263357,0.006679901,0.0003532589,0.000384737,0.005846178,0.02141069,0.00106152,0.02463659,0.1627627],"study_design_scores_gemma":[0.1771288,0.07184958,0.6877468,0.0003259269,0.006549355,0.001220061,0.0003659473,0.0107385,0.01316547,0.002176497,0.02859156,0.0001414363],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987347,0.002056119,0.0004708801,0.0005670442,0.00007554673,0.000509017,0.007073579,0.00003632201,0.001864409],"genre_scores_gemma":[0.9830566,0.0007044168,0.00144817,0.0005176992,0.00006333231,0.001292903,0.011633,0.00003504012,0.001248932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002714632,"threshold_uncertainty_score":0.01435655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333542339404392,"score_gpt":0.2909192706836354,"score_spread":0.2675838472895915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}