{"id":"W3110925972","doi":"10.1093/neuonc/noaa222.370","title":"IMMU-14. IMMUNE CHECKPOINT INHIBITOR THERAPY FOR TREATMENT OF SYNCHRONOUS CANCERS IN PAEDIATRIC PATIENTS WITH CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Microsatellite instability; DNA mismatch repair; Medicine; Cancer; Oncology; Germline; Internal medicine; Cancer research; Biology; Colorectal cancer; Gene; Allele; Microsatellite; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562025,0.0002290511,0.000453758,0.000272261,0.0002322331,0.0001750717,0.000178399,0.0002808987,0.0005463358],"category_scores_gemma":[0.0003338429,0.00009068246,0.0002992418,0.0002249472,0.0002190906,0.0001289113,0.0002655828,0.0006006125,0.0001724584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004326387,"about_ca_system_score_gemma":0.0005651766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005889182,"about_ca_topic_score_gemma":0.001858733,"domain_scores_codex":[0.9999249,0.00001564257,0.000009250503,0.00001395047,0.00001590727,0.00002029882],"domain_scores_gemma":[0.9998348,0.0000240744,0.00006055195,0.000008084295,0.00001259913,0.00005982898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004896869,0.00109796,0.4144768,0.001501296,0.0003762379,0.09566399,0.0009466662,0.002945142,0.1197982,0.002263271,0.007522413,0.3485111],"study_design_scores_gemma":[0.0009460935,0.01620746,0.5961742,0.0003569997,0.0003628283,0.2586372,0.0004592342,0.004480178,0.07530849,0.00106548,0.04594002,0.0000616741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813361,0.01223912,0.002266674,0.0005994505,0.00007699641,0.00008490446,0.0002289639,0.00008538752,0.003082476],"genre_scores_gemma":[0.9944213,0.002389143,0.002223331,0.000218617,0.00003175516,0.00003710965,0.0002477163,0.000009057601,0.0004219429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005889182,"threshold_uncertainty_score":0.003139019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901834200951528,"score_gpt":0.2725415698505383,"score_spread":0.253523227841023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}