{"id":"W3110928912","doi":"10.1093/neuonc/noaa222.536","title":"MBRS-20. CSF-DERIVED CIRCULATING TUMOR DNA AS A BIOMARKER FOR DISEASE PROGRESSION AND TUMOR EVOLUTION IN MEDULLOBLASTOMA","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Medicine; Copy-number variation; Oncology; Biomarker; Cell-free fetal DNA; Internal medicine; Prospective cohort study; Pathology; Genome; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007593803,0.0002426702,0.0003778711,0.0008729168,0.0002851213,0.0006478825,0.0003281635,0.0002913701,0.00090926],"category_scores_gemma":[0.002198341,0.0001159271,0.000260416,0.0005595674,0.0002716245,0.0003380044,0.0003774722,0.0002563538,0.0001508672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006449085,"about_ca_system_score_gemma":0.0004248028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004154099,"about_ca_topic_score_gemma":0.003299456,"domain_scores_codex":[0.9996399,0.00005888999,0.0000385652,0.0001144263,0.00008518709,0.00006301739],"domain_scores_gemma":[0.9987152,0.0002796372,0.0006122388,0.00006391349,0.0001417831,0.0001873732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000661385,0.00002834415,0.98615,0.00001924305,0.00004464544,0.0001435261,0.00006318199,0.0001831132,0.008025059,0.00002537497,0.00008145864,0.004574742],"study_design_scores_gemma":[0.00001415022,0.0004470669,0.9924845,0.000009321184,0.00005882361,0.0009771043,0.00009817095,0.000807719,0.00449757,0.00005346862,0.0005466781,0.00000532017],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987998,0.0004395888,0.0002285046,0.00001546634,0.000002923671,0.000009229861,0.0003479387,0.00001083518,0.0001457264],"genre_scores_gemma":[0.9992642,0.00007343901,0.0002781308,0.000007678875,0.000003601519,0.000009712841,0.0002786159,0.000003290231,0.00008132641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004154099,"threshold_uncertainty_score":0.008259833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513578644955156,"score_gpt":0.2860476733191931,"score_spread":0.2709118868696415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}