{"id":"W3110951180","doi":"10.1093/neuonc/noaa222.736","title":"RARE-25. RETINAL ASTROCYTOMA mTOR INHIBITOR THERAPY IN TUBEROUS SCLEROSIS MOSAICISM","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver General Hospital; Children's & Women's Health Centre of British Columbia","funders":"","keywords":"Tuberous sclerosis; Medicine; Retinal; Everolimus; Retina; mTORC1; Enucleation; Ophthalmology; Pathology; PI3K/AKT/mTOR pathway; Internal medicine; Surgery; Neuroscience; Psychology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003820639,0.0003859866,0.0009512893,0.0002748534,0.0001211546,0.00004504964,0.0004475742,0.0003645776,0.0008259917],"category_scores_gemma":[0.0006079976,0.0003633698,0.0001998029,0.0008483181,0.0003038064,0.0001325603,0.0003080049,0.001163643,0.0005646353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004948238,"about_ca_system_score_gemma":0.0005789774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001076018,"about_ca_topic_score_gemma":0.00007907229,"domain_scores_codex":[0.995943,0.0006196026,0.0007368376,0.0009474345,0.0007465724,0.001006615],"domain_scores_gemma":[0.997781,0.0006380372,0.000150772,0.0005505235,0.0001935515,0.0006860787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003739521,0.000554623,0.02321013,0.00004248337,0.00003308941,0.0009596249,0.001011112,0.00001109843,0.8913919,0.00008793718,0.02094876,0.05800974],"study_design_scores_gemma":[0.03679412,0.05443726,0.2849842,0.0002702571,0.00009718378,0.001843782,0.0008939024,0.001963201,0.2840223,0.00008871941,0.3335221,0.001083005],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581716,0.0003369017,0.00003865503,0.03661888,0.0003838938,0.001173128,0.00001893929,0.000251074,0.003006945],"genre_scores_gemma":[0.9815946,0.0002563279,0.001318693,0.01536466,0.001106627,0.0001762099,0.00002600974,0.000109431,0.0000474718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6073696,"threshold_uncertainty_score":0.9998818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08722362094705445,"score_gpt":0.3218538980837035,"score_spread":0.2346302771366491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}