{"id":"W3110982918","doi":"10.1101/2020.12.04.20242115","title":"Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval; Centre hospitalier de l'Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cytokine storm; Cyclooxygenase; Inflammation; Lipoxygenase; Eicosanoid; Arachidonic acid; Eicosapentaenoic acid; Medicine; Lung; Pneumonia; Respiratory distress; Docosahexaenoic acid; Immunology; Internal medicine; Coronavirus disease 2019 (COVID-19); Chemistry; Polyunsaturated fatty acid; Biochemistry; Fatty acid; Disease; Anesthesia; Enzyme; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883673,0.0003538296,0.0004252473,0.0007608768,0.0003569858,0.0004339389,0.0001206258,0.000345333,0.001213541],"category_scores_gemma":[0.000410892,0.0001459003,0.0001565626,0.0003356186,0.0003409103,0.0002167174,0.0003463188,0.0002972933,0.0001983767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299624,"about_ca_system_score_gemma":0.0001122094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003727922,"about_ca_topic_score_gemma":0.0004345483,"domain_scores_codex":[0.9998116,0.00002820732,0.00002533721,0.00005715255,0.00003996868,0.00003776127],"domain_scores_gemma":[0.999763,0.00004382928,0.00007933605,0.00001235352,0.00003082458,0.00007064314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002189043,0.0001538642,0.7709954,0.0001212524,0.0000997176,0.006194743,0.0005537166,0.00008014529,0.2127287,0.000054514,0.000107761,0.006721112],"study_design_scores_gemma":[0.00002263389,0.00131605,0.9730713,0.00001484894,0.0000632212,0.00819083,0.0006972947,0.0002784307,0.01570563,0.00006772296,0.0005613105,0.00001085388],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990658,0.000470822,0.0001575427,0.00001316124,0.00000381881,0.0000128133,0.0001156234,0.000003909009,0.0001564375],"genre_scores_gemma":[0.9994123,0.0001297781,0.0001656228,0.00003195724,0.00001007855,0.00000840713,0.000140064,0.000001373267,0.0001002801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213541,"threshold_uncertainty_score":0.004059732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05916364458349792,"score_gpt":0.3621939813702704,"score_spread":0.3030303367867724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}