{"id":"W3110984253","doi":"10.1002/jimd.12343","title":"Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency","year":2020,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Wayne State University; Children's Hospital of Michigan; Aeglea BioTherapeutics; Stanford University","keywords":"Medicine; Adverse effect; Spasticity; Dosing; Internal medicine; Gastroenterology; Arginine; Arginase; Vomiting; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005963661,0.0002629719,0.0005904585,0.0001116803,0.0001159966,0.0002896724,0.0001437803,0.0003454415,0.0006596325],"category_scores_gemma":[0.001094982,0.00007108784,0.0003502076,0.0001294199,0.0001737907,0.0001873978,0.000114675,0.0006653648,0.0001824193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796199,"about_ca_system_score_gemma":0.0001987845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002319616,"about_ca_topic_score_gemma":0.0002934934,"domain_scores_codex":[0.9997709,0.0001011081,0.00002771697,0.0000349357,0.00003957978,0.00002573409],"domain_scores_gemma":[0.9994889,0.0001585597,0.0001553022,0.00003234077,0.00004135879,0.000123506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1638603,0.007405313,0.2064956,0.0008137703,0.001003742,0.004165489,0.0006157934,0.003120485,0.1467641,0.0002461411,0.002601952,0.4629074],"study_design_scores_gemma":[0.01838766,0.3991588,0.5316306,0.000111032,0.0007981248,0.01014967,0.0002912357,0.003422655,0.02656757,0.0002338021,0.00918902,0.00005983818],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966636,0.002140873,0.0002070106,0.0001171084,0.00001061614,0.00003990882,0.0001538439,0.00001486693,0.0006521867],"genre_scores_gemma":[0.9984285,0.0006601921,0.0001631364,0.0001396689,0.00002637777,0.00002752707,0.0002988593,0.000002247962,0.0002534528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006596325,"threshold_uncertainty_score":0.003153861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005981346592991933,"score_gpt":0.2467753749051154,"score_spread":0.2407940283121235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}