{"id":"W3110984253","doi":"10.1002/jimd.12343","title":"Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency","year":2020,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Wayne State University; Children's Hospital of Michigan; Aeglea BioTherapeutics; Stanford University","keywords":"Medicine; Adverse effect; Spasticity; Dosing; Internal medicine; Gastroenterology; Arginine; Arginase; Vomiting; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004274341,0.0001699474,0.0004552047,0.00007524042,0.00002273145,0.00001180961,0.0001739522,0.00006776307,0.00002642629],"category_scores_gemma":[0.0004619817,0.0001236869,0.0001356118,0.0002348195,0.0001425424,0.00001200991,0.00006427642,0.0001455984,0.000001215755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001287455,"about_ca_system_score_gemma":0.0001720279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002019846,"about_ca_topic_score_gemma":0.000001115509,"domain_scores_codex":[0.9984561,0.000238501,0.0006237701,0.0002334883,0.0002635643,0.0001845761],"domain_scores_gemma":[0.998815,0.00002254657,0.000364068,0.0001917139,0.0001763081,0.0004303551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008353404,0.0006809987,0.9630924,0.0001499901,0.00008128925,0.00002270692,0.00007082268,0.00008057102,0.002434729,0.00003626323,0.0004160445,0.02458073],"study_design_scores_gemma":[0.006854449,0.001145771,0.9780062,0.00004372086,0.0001687417,0.000001783552,0.00004103842,0.00002678086,0.0008440563,0.000009383769,0.0127026,0.0001554527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990202,0.008924237,0.0001736791,0.0001451833,0.00007852733,0.0002849151,0.00006141473,0.000002233543,0.0001278698],"genre_scores_gemma":[0.9976344,0.001033476,0.0007789162,0.0003830772,0.0001090202,0.00000416379,0.00002952235,0.00001820772,0.000009191533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02442528,"threshold_uncertainty_score":0.5043806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005981346592991933,"score_gpt":0.2467753749051154,"score_spread":0.2407940283121235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}