{"id":"W3111036614","doi":"10.1093/brain/awaa405","title":"Depression, dementia and immune dysregulation","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Carleton University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Dementia; Depression (economics); Medicine; Disease; Antidepressant; Cognitive decline; Proinflammatory cytokine; Immune dysregulation; Stroke (engine); Chronic stress; Psychology; Neuroscience; Inflammation; Psychiatry; Immunology; Internal medicine; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003592158,0.00005392517,0.00005307639,0.00001603926,0.00007176593,0.00002918233,0.00007549983,0.00002330203,0.0001316651],"category_scores_gemma":[0.0003748323,0.00004899011,0.00001653555,0.0001127204,0.00004094633,0.00009204578,0.0000535297,0.000040842,0.00004470007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001860825,"about_ca_system_score_gemma":0.000006397755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002442454,"about_ca_topic_score_gemma":0.000001001149,"domain_scores_codex":[0.9994973,0.00004241234,0.00008247585,0.0001925337,0.00008802964,0.00009724354],"domain_scores_gemma":[0.999768,0.00007175261,0.00002742495,0.00007194107,0.000004077133,0.00005679949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001692994,0.00001187894,0.001049302,0.000009298537,0.000001905678,0.000003465971,0.0003449243,0.000009710694,0.9703624,0.002296465,0.004857825,0.02103588],"study_design_scores_gemma":[0.001275988,0.00006049739,0.1939532,0.0000140576,0.000005971913,0.000007904891,0.0001118195,0.003760165,0.7565562,0.002931267,0.04109562,0.0002273533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770818,0.0004346025,0.001656776,0.01535145,0.00007233204,0.0001655334,0.000003811578,0.0001328949,0.005100789],"genre_scores_gemma":[0.9938323,0.00000675829,0.0001448905,0.005840206,0.00003215661,0.000003203851,0.000001480928,0.000007202466,0.0001317398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2138063,"threshold_uncertainty_score":0.1997759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143355057566519,"score_gpt":0.2424141932091069,"score_spread":0.2209806426334417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}