{"id":"W3111047021","doi":"10.1158/2159-8290.cd-20-0652","title":"MNK Inhibition Sensitizes <i>KRAS</i> -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"H2020 European Research Council; Biotechnology and Biological Sciences Research Council; Wellcome; Medical Research Council; Cancer Research UK; Wellcome Trust; Pancreatic Cancer UK","keywords":"KRAS; mTORC1; Cancer research; Colorectal cancer; Mutant; Biology; EIF4E; Cancer; Translation (biology); Mutation; Population; PI3K/AKT/mTOR pathway; Signal transduction; Messenger RNA; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008231289,0.0003281779,0.0002593535,0.0002315204,0.0001379033,0.0002324307,0.000163215,0.0002015317,0.001585957],"category_scores_gemma":[0.0000597337,0.0001137654,0.0002460629,0.0001180206,0.0001681053,0.0001081852,0.0001397316,0.0005978622,0.0003476423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315436,"about_ca_system_score_gemma":0.0001788149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008284904,"about_ca_topic_score_gemma":0.002059808,"domain_scores_codex":[0.9999123,0.000009350898,0.0000102082,0.00002051427,0.00002289536,0.00002474847],"domain_scores_gemma":[0.999951,0.000006113005,0.00001347504,0.000007145245,0.000005161937,0.00001717094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001786397,0.00007249299,0.00024097,0.00004154875,0.000007686207,0.00002569219,0.000007846667,0.0001070794,0.9971327,0.00005821,0.0001566476,0.001970466],"study_design_scores_gemma":[0.00001917949,0.0008290402,0.002850404,0.000004007172,0.00001427699,0.0002279661,0.0000111779,0.0004121795,0.9932941,0.00001934052,0.002314849,0.00000340924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937168,0.001164629,0.001513059,0.0001652787,0.00005919927,0.00006616443,0.0006739651,0.0002864862,0.002354394],"genre_scores_gemma":[0.9949844,0.0006849688,0.001504459,0.00007538543,0.000009018699,0.00004553775,0.0005214032,0.00002783906,0.002146977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585957,"threshold_uncertainty_score":0.005305588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009508269855752996,"score_gpt":0.2471253655616887,"score_spread":0.2376170957059357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}