{"id":"W3111047525","doi":"10.3899/jrheum.200893","title":"Safety and Efficacy of Poseltinib, Bruton’s Tyrosine Kinase Inhibitor, in Patients With Rheumatoid Arthritis: A Randomized, Double-blind, Placebo-controlled, 2-part Phase II Study","year":2020,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Tolerability; Clinical endpoint; Adverse effect; Rheumatology; Interim analysis; Gastroenterology; Randomized controlled trial; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004623236,0.002265543,0.003869356,0.0004927666,0.0006245935,0.001205055,0.0009887966,0.002573698,0.005604429],"category_scores_gemma":[0.00250901,0.001092499,0.002217985,0.0004897089,0.001400234,0.00128073,0.0003533582,0.002941804,0.001315497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008268062,"about_ca_system_score_gemma":0.001781113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004574417,"about_ca_topic_score_gemma":0.001267407,"domain_scores_codex":[0.998495,0.0008737365,0.0001006449,0.0002382452,0.0001406365,0.0001516581],"domain_scores_gemma":[0.9983703,0.0004166568,0.0003717444,0.0001406178,0.000152407,0.0005481153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9575715,0.01608019,0.001003789,0.0005758143,0.0006611806,0.0000569572,0.0000521145,0.0002694752,0.004657284,0.00006377346,0.0009082533,0.01809963],"study_design_scores_gemma":[0.9142749,0.08275308,0.001570712,0.00001778284,0.0002533266,0.00003666477,0.00000859235,0.0002172831,0.00035684,0.00005258145,0.0004481547,0.00001016633],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737746,0.007657525,0.001342464,0.001184002,0.0007157911,0.01059099,0.002032391,0.0001689697,0.002533334],"genre_scores_gemma":[0.9772699,0.003524915,0.002313747,0.002366608,0.0009324377,0.008866289,0.001861575,0.00003023721,0.002834286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005604429,"threshold_uncertainty_score":0.0244503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403249122080261,"score_gpt":0.2740266649939141,"score_spread":0.2599941737731115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}