{"id":"W3111048839","doi":"10.1016/j.psychres.2020.113649","title":"Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression","year":2020,"lang":"en","type":"article","venue":"Psychiatry Research","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Greenwich Biosciences; Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis; Agency for Healthcare Research and Quality; National Institutes of Health; Spier Family Foundation; Rogers Family Foundation; Eli Lilly and Company; Canadian Network for Mood and Anxiety Treatments; Assurex Health; Cerecor; Myriad Genetics; Sunovion; H. Lundbeck A/S; National Institute of Mental Health; Avanir Pharmaceuticals; Eisai; ACADIA Pharmaceuticals; Sage Therapeutics; University of Kansas; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; Stanley Medical Research Institute; Pfizer; Biogen; Allergan; Cancer Research Institute; AstraZeneca; Bristol-Myers Squibb; LivaNova; Ontario Brain Institute","keywords":"Medicine; Pharmacogenomics; Major depressive disorder; Pharmacogenetics; Depression (economics); Hamilton Rating Scale for Depression; Clinical trial; Internal medicine; Psychiatry; Pharmacology; Mood; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00924758,0.0008347275,0.001287336,0.0006854472,0.0003786,0.001148913,0.0006996455,0.0008825147,0.0007972262],"category_scores_gemma":[0.02858733,0.0003522278,0.001216009,0.001067052,0.0005787108,0.0006143961,0.0007441229,0.0009912536,0.0002251889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004118463,"about_ca_system_score_gemma":0.00090266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162951,"about_ca_topic_score_gemma":0.00226114,"domain_scores_codex":[0.988475,0.007419672,0.0007797269,0.001622245,0.001377492,0.0003259284],"domain_scores_gemma":[0.9695194,0.01774899,0.006903191,0.00265568,0.002178868,0.0009938201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007517498,0.0004757761,0.9706904,0.00007870174,0.001663988,0.00006295473,0.0001216316,0.001720472,0.0006068865,0.0001163132,0.0002528438,0.01669259],"study_design_scores_gemma":[0.002262589,0.01148792,0.9621,0.00009689653,0.002521024,0.0004109346,0.0001806821,0.0175027,0.001541694,0.001054117,0.0007741694,0.00006722011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99655,0.0004864999,0.001313411,0.0001664577,0.00002192589,0.0001264494,0.0004759048,0.00001714483,0.0008421129],"genre_scores_gemma":[0.9971344,0.00007458781,0.002020719,0.0001179367,0.0000277261,0.0001037138,0.0004323731,0.00000486594,0.00008362876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00924758,"threshold_uncertainty_score":0.04890651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3817571634389512,"score_gpt":0.5489436165382022,"score_spread":0.1671864530992511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}