{"id":"W3111090709","doi":"10.1186/s13287-020-02047-1","title":"Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; University of Guelph; Lawson Health Research Institute; University of Toronto; Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reprogramming; Biology; Gene expression profiling; Fibroblast; Stem cell; Cell biology; Developmental biology; Molecular biology; Computational biology; Gene expression; Cell culture; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001316912,0.0003386221,0.0004435507,0.0001321355,0.0002787497,0.0001052892,0.0007924405,0.0002634914,0.00009399413],"category_scores_gemma":[0.0001227201,0.0002933536,0.0001647876,0.0006891974,0.0002791842,0.00002014719,0.0004534686,0.0005224972,0.00002978441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004799306,"about_ca_system_score_gemma":0.0002056454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001486703,"about_ca_topic_score_gemma":0.000008135808,"domain_scores_codex":[0.9950944,0.001053891,0.0005871344,0.001068955,0.001170406,0.001025235],"domain_scores_gemma":[0.9976964,0.0001282414,0.0002851613,0.0008309377,0.0005928467,0.0004663947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001549968,0.0001567709,0.008485955,0.0002747561,0.00006801216,0.00002920384,0.0002556904,0.00009031536,0.982544,0.000001558334,0.004918852,0.001624931],"study_design_scores_gemma":[0.001159179,0.002007745,0.0008445599,0.0001654945,0.000003610201,0.000001892931,0.0004061143,0.0001899173,0.9895632,0.00001148826,0.005362146,0.000284624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920107,0.005695153,0.0001297526,0.0003259923,0.00002823562,0.001284452,0.0002202549,0.00005105302,0.0002544662],"genre_scores_gemma":[0.9940324,0.001077651,0.0003506133,0.00003603316,0.0001496308,0.0001045474,0.0003369103,0.00009817204,0.003814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007641396,"threshold_uncertainty_score":0.9999518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04155879935363269,"score_gpt":0.3091815282758983,"score_spread":0.2676227289222657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}