{"id":"W3111151965","doi":"10.1002/alz.038980","title":"Optimization of <i>in vitro</i> gene delivery to neurons containing an APP gene with a mutation responsible for familial Alzheimer’s disease for the development of a base editing therapy","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Amyloid precursor protein; Gene; Genome editing; Mutation; CRISPR; Viral vector; Molecular biology; Biology; Genetic enhancement; Amyloid precursor protein secretase; Cas9; Hippocampal formation; Genetics; Alzheimer's disease; Disease; Recombinant DNA; Medicine; Neuroscience; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003538201,0.0004015584,0.0002974739,0.0001339508,0.0001662872,0.0006022109,0.0003236435,0.0003362975,0.000801708],"category_scores_gemma":[0.000202396,0.0001645448,0.0003191409,0.0000851074,0.0001614608,0.000196709,0.0001844513,0.0004447972,0.0004098774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004157075,"about_ca_system_score_gemma":0.0002206516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075701,"about_ca_topic_score_gemma":0.001157803,"domain_scores_codex":[0.999763,0.00005015285,0.00002737905,0.00005586637,0.00007291987,0.00003063208],"domain_scores_gemma":[0.999904,0.00001902785,0.0000302002,0.000009213017,0.00002437188,0.00001318489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002397848,0.00002080568,0.00004825808,0.00002664668,0.000003777544,0.00001768963,0.000008748771,0.0001716919,0.9989578,0.00005955141,0.00002683381,0.000634304],"study_design_scores_gemma":[0.000004707783,0.0001899348,0.0002990632,0.000003924163,0.00001349141,0.00004706672,0.00000903974,0.001074253,0.9973514,0.00001667398,0.0009864465,0.000004071892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667042,0.001396723,0.02712832,0.0001001777,0.00006597896,0.000196131,0.0003332775,0.0001377807,0.003937341],"genre_scores_gemma":[0.9782872,0.0009973218,0.01784592,0.00005526689,0.000008593459,0.0001539296,0.0002882583,0.00005966499,0.002303901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075701,"threshold_uncertainty_score":0.003016233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06210487018068482,"score_gpt":0.3121272732356418,"score_spread":0.250022403054957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}