{"id":"W3111160935","doi":"10.1002/alz.042298","title":"Development of [<sup>18</sup>F]SNFT‐1, a novel tau PET tracer with little off‐target binding","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Chemistry; Biodistribution; Monoamine oxidase; In vitro; Monoamine oxidase B; Binding potential; Monoamine oxidase A; Toxicity; Receptor; Pharmacology; Biochemistry; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598421,0.000615422,0.0003431891,0.000226715,0.0001675386,0.0003469553,0.0005988465,0.0006823881,0.0009658498],"category_scores_gemma":[0.0002033932,0.0002786599,0.0002526023,0.0001429413,0.0003097851,0.0004539337,0.0001438719,0.0006173778,0.0005700709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005900762,"about_ca_system_score_gemma":0.0005203156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001604936,"about_ca_topic_score_gemma":0.001723881,"domain_scores_codex":[0.9999108,0.00001531612,0.000004267239,0.00002745994,0.00002427844,0.00001772358],"domain_scores_gemma":[0.9999171,0.0000110482,0.00002190685,0.00000675243,0.00002072782,0.00002239421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001661787,0.00005606448,0.0001925267,0.0001168021,0.00001180552,0.0001790093,0.00002041229,0.0004146501,0.9862726,0.0003256818,0.0002399658,0.01200441],"study_design_scores_gemma":[0.00006580805,0.001233579,0.000756474,0.00001217264,0.00004024876,0.001178278,0.00001361623,0.00229629,0.9870523,0.00007538946,0.007262188,0.00001376446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8785682,0.01756682,0.0917994,0.0009549831,0.0001526173,0.0005499672,0.0007958717,0.0006212813,0.008990898],"genre_scores_gemma":[0.9115298,0.007905712,0.06875307,0.000382918,0.00006764881,0.0003343216,0.00166488,0.00008042149,0.009281164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001604936,"threshold_uncertainty_score":0.004281282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05413062105636238,"score_gpt":0.3002664606816442,"score_spread":0.2461358396252818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}