{"id":"W3111170629","doi":"10.1016/s2152-2650(20)30716-3","title":"AML-123: Targeted Conditioning with Anti-CD45 Iodine (131I) Apamistamab [Iomab-B] Leads to High Rates of Transplantation and Engraftment in Older Patients with Active, Relapsed, or Refractory (rel/ref) AML: Preliminary Midpoint Results from the Prospective, Randomized Phase 3 SIERRA Trial","year":2020,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Internal medicine; Neutropenia; Context (archaeology); Transplantation; Febrile neutropenia; Rituximab; Salvage therapy; Venetoclax; Refractory (planetary science); Bendamustine; Surgery; Gastroenterology; Leukemia; Lymphoma; Chemotherapy; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009190089,0.0005903663,0.001026736,0.0001717694,0.0001682084,0.0007073814,0.0004173683,0.0005267471,0.001965965],"category_scores_gemma":[0.0006407259,0.0001753017,0.0006642453,0.0002350802,0.0004335991,0.0004728567,0.0003171355,0.001479727,0.0004607341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004068526,"about_ca_system_score_gemma":0.0005076864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006840657,"about_ca_topic_score_gemma":0.001666905,"domain_scores_codex":[0.9997414,0.0001322485,0.00001245639,0.00004171895,0.00002728172,0.00004480552],"domain_scores_gemma":[0.9995645,0.00008857253,0.0001059914,0.0000333434,0.0000159193,0.0001915785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6604995,0.01136922,0.02143053,0.000573998,0.002295104,0.0002081246,0.0002046199,0.002080528,0.08137339,0.0005434226,0.005845794,0.2135757],"study_design_scores_gemma":[0.5746017,0.2434098,0.1484842,0.0001084354,0.002912379,0.001076346,0.0001221252,0.003461675,0.01582467,0.0007924417,0.009102643,0.000103736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996278,0.001705608,0.0003146106,0.0003224211,0.00005238952,0.0001240655,0.0002663809,0.00007502434,0.0008614747],"genre_scores_gemma":[0.9958029,0.001124018,0.0006713974,0.0005366676,0.00008549584,0.0001184732,0.0008865232,0.00002704768,0.0007475682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965965,"threshold_uncertainty_score":0.006576836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365138809782435,"score_gpt":0.2799110546235407,"score_spread":0.2662596665257163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}