{"id":"W3111196701","doi":"10.1136/bmjopen-2020-041319","title":"Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol","year":2020,"lang":"en","type":"article","venue":"BMJ Open","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; BC Children's Hospital; University of British Columbia; McMaster University; Children's Hospital of Eastern Ontario; Institute for Clinical Evaluative Sciences; University of Ottawa; Women and Children’s Health Research Institute; University of Alberta; Children's Hospital of Winnipeg; Hospital for Sick Children; Western University; University of Toronto; Children’s Health Research Institute; McMaster Children's Hospital; London Health Sciences Centre; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Ontario Ministry of Economic Development, Job Creation and Trade; Ministero dello Sviluppo Economico; University of Alberta; Centre hospitalier universitaire Sainte-Justine; Children's Health Foundation; Children's Health Research Institute; London Health Sciences Foundation; Alberta Children's Hospital Research Institute; Academic Medical Organization of Southwestern Ontario; Women and Children's Health Research Institute","keywords":"Medicine; Dexmedetomidine; Ketamine; Sedation; Randomized controlled trial; Anesthesia; Adverse effect; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01720761,0.004752628,0.007430525,0.001117717,0.001130136,0.003333094,0.002509601,0.006417628,0.0278394],"category_scores_gemma":[0.02694415,0.001607782,0.003749649,0.001386752,0.003227694,0.003112134,0.001342403,0.005076023,0.004332405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00237107,"about_ca_system_score_gemma":0.006642752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000857993,"about_ca_topic_score_gemma":0.001713626,"domain_scores_codex":[0.9864153,0.009343138,0.001063247,0.0011057,0.00103087,0.00104164],"domain_scores_gemma":[0.9924067,0.002741166,0.002317348,0.0007543119,0.0007341785,0.001046351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9620568,0.002634966,0.0005087156,0.01316513,0.002118191,0.0001504863,0.0002153578,0.000919233,0.001012348,0.001965877,0.004317593,0.0109353],"study_design_scores_gemma":[0.9787176,0.0127641,0.0006574502,0.001020564,0.0006814582,0.00005537089,0.00003734225,0.000659376,0.00024234,0.001079463,0.00404696,0.00003793964],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04343364,0.004131137,0.004809871,0.001736483,0.001650887,0.9373127,0.003051803,0.0002858946,0.00358762],"genre_scores_gemma":[0.04662679,0.001490712,0.006374063,0.00126493,0.0002966904,0.9409602,0.0006970017,0.00002685703,0.002262834],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0278394,"threshold_uncertainty_score":0.09313202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1099808382500172,"score_gpt":0.4231320231586631,"score_spread":0.3131511849086459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}