{"id":"W3111283167","doi":"10.21203/rs.3.rs-115316/v1","title":"Plasma p tau 181 are associated with white matter microstructural changes in Alzheimer’s disease","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Fractional anisotropy; Biomarker; White matter; Neurodegeneration; Internal medicine; Oncology; Psychology; Alzheimer's disease; Disease; Cognitive decline; Medicine; Endocrinology; Neuroscience; Chemistry; Dementia; Magnetic resonance imaging; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.005057394,0.001658273,0.002424129,0.004286066,0.00113987,0.001121138,0.002071833,0.001180986,0.003401084],"category_scores_gemma":[0.0031204,0.001361701,0.0007048325,0.004619301,0.002655876,0.0004170145,0.004832466,0.01200712,0.002284302],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003033486,"about_ca_system_score_gemma":0.007116191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002371298,"about_ca_topic_score_gemma":0.004313337,"domain_scores_codex":[0.9711061,0.005651137,0.001181885,0.003960983,0.01179057,0.006309336],"domain_scores_gemma":[0.9829096,0.002140121,0.000395716,0.003175288,0.005147148,0.006232131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01267219,0.003124395,0.9048092,0.003708854,0.01099287,0.02369672,0.001395301,0.00008461172,0.000114944,0.00006174361,0.0377253,0.001613848],"study_design_scores_gemma":[0.008721305,0.002790613,0.9690152,0.01029615,0.0007467494,0.00005336761,0.002141608,0.001554201,0.0006955059,0.001410496,0.001152552,0.001422269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9082131,0.01922288,0.000005161148,0.04818209,0.000244011,0.01537314,0.006060559,0.0004617331,0.002237268],"genre_scores_gemma":[0.9847626,0.001638361,0.0001683775,0.000311389,0.0008845186,0.004036537,0.006981772,0.0005427503,0.0006736778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07654946,"threshold_uncertainty_score":0.9999158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111060147245317,"score_gpt":0.4014686183155855,"score_spread":0.2904084710702685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}