{"id":"W3111283167","doi":"10.21203/rs.3.rs-115316/v1","title":"Plasma p tau 181 are associated with white matter microstructural changes in Alzheimer’s disease","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Fractional anisotropy; Biomarker; White matter; Neurodegeneration; Internal medicine; Oncology; Psychology; Alzheimer's disease; Disease; Cognitive decline; Medicine; Endocrinology; Neuroscience; Chemistry; Dementia; Magnetic resonance imaging; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002906603,0.0003521404,0.0003065019,0.0006673498,0.0002619532,0.0004984197,0.0001223372,0.0003627301,0.003036097],"category_scores_gemma":[0.001221544,0.0001625967,0.0002057667,0.0005057431,0.0002014867,0.0002469255,0.0002278929,0.000310649,0.0005255555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023994,"about_ca_system_score_gemma":0.0001084484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000493257,"about_ca_topic_score_gemma":0.0002578094,"domain_scores_codex":[0.9998668,0.00002940264,0.00001818792,0.00004251314,0.00002837184,0.00001463565],"domain_scores_gemma":[0.9994813,0.0001062308,0.0002512364,0.00004852045,0.00006698076,0.00004581066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005274053,0.0002901484,0.9106076,0.0002528879,0.0005141261,0.002283921,0.0005068494,0.0003421847,0.05255636,0.0002822293,0.001661967,0.02542766],"study_design_scores_gemma":[0.00002545762,0.0002239392,0.9908154,0.00001438789,0.0001070352,0.00234616,0.0001413873,0.0003812699,0.004331744,0.0007043244,0.0009014677,0.000007451012],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973329,0.0008162486,0.0004600204,0.0000869962,0.00002614612,0.00000808088,0.0004613307,0.00002073958,0.0007873812],"genre_scores_gemma":[0.9984081,0.0002060851,0.0004276022,0.00002736895,0.00002829157,0.000007687435,0.0003372647,0.000007112848,0.0005504861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003036097,"threshold_uncertainty_score":0.01015681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.111060147245317,"score_gpt":0.4014686183155855,"score_spread":0.2904084710702685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}