{"id":"W3111311463","doi":"10.1002/alz.041045","title":"Cognitive dysfunction induced by ketamine and xylazine anesthesia is associated with tau hyperphosphorylation following CaMKII activation","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Xylazine; Ketamine; Hyperphosphorylation; Anesthetic; Pharmacology; Phosphorylation; Medicine; Morris water navigation task; Anesthesia; Neuroscience; Hippocampus; Endocrinology; Chemistry; Psychology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178857,0.0006037902,0.0003020793,0.0002714063,0.0001458854,0.0002071895,0.0001494365,0.000199185,0.001126832],"category_scores_gemma":[0.000110551,0.0001518354,0.0003367552,0.0001515836,0.0002738143,0.0001795317,0.0001374616,0.0008264935,0.0001903627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427556,"about_ca_system_score_gemma":0.0002385089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969258,"about_ca_topic_score_gemma":0.001222641,"domain_scores_codex":[0.9998966,0.00001049452,0.00001184951,0.00001982611,0.00002514843,0.00003603652],"domain_scores_gemma":[0.9998525,0.000005356468,0.00009269849,0.000007970692,0.00001200329,0.00002938358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012423,0.0001166425,0.001053591,0.0000769252,0.00002495082,0.0001485784,0.00001968766,0.00002799574,0.9951,0.00006217603,0.00007754679,0.002279628],"study_design_scores_gemma":[0.0001162919,0.002983707,0.08777694,0.00003928752,0.000117346,0.001331616,0.00009733153,0.0007759579,0.9049468,0.0001733984,0.001627916,0.000013375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938383,0.003071406,0.001618885,0.0001372545,0.00004092887,0.00003961483,0.0002308476,0.00008838114,0.000934506],"genre_scores_gemma":[0.9952372,0.001997281,0.001313585,0.00008870489,0.0000181112,0.00007506585,0.0002976308,0.00001073622,0.0009615698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126832,"threshold_uncertainty_score":0.003769636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0546825537565833,"score_gpt":0.2733203265083777,"score_spread":0.2186377727517944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}