{"id":"W3111311463","doi":"10.1002/alz.041045","title":"Cognitive dysfunction induced by ketamine and xylazine anesthesia is associated with tau hyperphosphorylation following CaMKII activation","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Xylazine; Ketamine; Hyperphosphorylation; Anesthetic; Pharmacology; Phosphorylation; Medicine; Morris water navigation task; Anesthesia; Neuroscience; Hippocampus; Endocrinology; Chemistry; Psychology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461205,0.000222289,0.0002193614,0.0000640338,0.0003086855,0.0001045067,0.000119029,0.0001011251,0.00008235755],"category_scores_gemma":[0.000264404,0.0002036458,0.00004988905,0.0005532458,0.00007248959,0.0005278387,0.00003844033,0.0002266475,0.00004446113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008749525,"about_ca_system_score_gemma":0.00004326001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003669646,"about_ca_topic_score_gemma":0.000002525571,"domain_scores_codex":[0.9981414,0.0001986185,0.000213066,0.0005814451,0.0005446745,0.0003207791],"domain_scores_gemma":[0.9992653,0.0002488243,0.000145578,0.0001108529,0.00006866617,0.0001608142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002941388,0.0001244903,0.008356546,0.00000369784,0.0007275696,0.00006441036,0.0006255481,0.00000134288,0.9818891,0.00003087017,0.0007410606,0.007141179],"study_design_scores_gemma":[0.001352235,0.0007029377,0.01971261,0.00003025673,0.001425327,0.0000172969,0.00009518366,0.0009469183,0.9748113,0.00001054181,0.0006239766,0.0002713758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949905,0.0004720734,0.000277479,0.003304526,0.00001909124,0.0006652605,0.000004620292,0.000110048,0.0001563503],"genre_scores_gemma":[0.9950771,0.00002588709,0.00001898993,0.004693349,0.00002927998,0.00005613438,0.00004121942,0.00004113527,0.00001693359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01135607,"threshold_uncertainty_score":0.8304433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0546825537565833,"score_gpt":0.2733203265083777,"score_spread":0.2186377727517944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}