{"id":"W3111343982","doi":"10.1093/neuonc/noab195.011","title":"Chemotherapy strategies for young children newly diagnosed with desmoplastic/extensive nodular medulloblastoma up to the era of molecular profiling – a comparative outcomes analysis of prospective multi-center European and North American trials.","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Medulloblastoma; Medicine; Oncology; Induction chemotherapy; Chemotherapy; Internal medicine; Clinical trial; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00446376,0.0004064586,0.001110284,0.0008274569,0.0001951429,0.0007220453,0.0003786412,0.0005547609,0.0008625967],"category_scores_gemma":[0.003807774,0.0002097731,0.001939645,0.0009915361,0.000414716,0.0006869579,0.0003385427,0.0007360915,0.0001029343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001090366,"about_ca_system_score_gemma":0.0008591858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094938,"about_ca_topic_score_gemma":0.004957922,"domain_scores_codex":[0.9972138,0.001844565,0.0003507953,0.0002601073,0.0001952152,0.0001355105],"domain_scores_gemma":[0.996823,0.00122122,0.001351074,0.0001469529,0.0001610318,0.000296743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.552574,0.003838436,0.07627466,0.005720526,0.02458817,0.0002584691,0.000273309,0.003207032,0.0049341,0.0006195299,0.001637653,0.3260742],"study_design_scores_gemma":[0.2307476,0.3800991,0.3032055,0.003955742,0.04952567,0.001836294,0.0007462892,0.001905179,0.006039558,0.0009052561,0.02088888,0.0001449919],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8593963,0.1363696,0.000425476,0.0003373481,0.0001031923,0.0008389101,0.0008619744,0.00001825438,0.001649017],"genre_scores_gemma":[0.9749396,0.02181208,0.0008096391,0.0004263351,0.0001041031,0.0005879259,0.001036572,0.000006476563,0.0002771354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00446376,"threshold_uncertainty_score":0.0236069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02763661128966926,"score_gpt":0.3232738792523911,"score_spread":0.2956372679627219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}