{"id":"W3111348072","doi":"10.1016/j.psychres.2020.113646","title":"Biological aging in schizophrenia and psychosis severity: DNA methylation analysis","year":2020,"lang":"en","type":"article","venue":"Psychiatry Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Department of Psychiatry, University of Toronto","keywords":"Epigenetics; dNaM; DNA methylation; Psychosis; Schizophrenia (object-oriented programming); Brief Psychiatric Rating Scale; Methylation; Correlation; Medicine; Internal medicine; Clinical psychology; Psychiatry; Psychology; Biology; Oncology; Bioinformatics; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006893369,0.00009574119,0.0001409504,0.0002117614,0.00007713602,0.00003963537,0.0001281837,0.000140995,0.00006209668],"category_scores_gemma":[0.0001457034,0.00009024637,0.0000618255,0.0009544951,0.00007310846,0.000003508507,0.0001128216,0.0001836797,0.00001386764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006644205,"about_ca_system_score_gemma":0.0000312845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000430503,"about_ca_topic_score_gemma":0.0002315066,"domain_scores_codex":[0.9986551,0.0002796018,0.000183101,0.0004555596,0.0001860464,0.0002405946],"domain_scores_gemma":[0.9995576,0.00002499902,0.00003446196,0.0001933083,0.00005497833,0.0001347249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001455737,0.00005531266,0.7969159,0.00001605185,0.000146369,8.341135e-7,0.0000745865,0.00005515681,0.1902523,0.0002247809,0.0002959637,0.01181718],"study_design_scores_gemma":[0.0009895476,0.0004328162,0.9677584,0.000009991093,0.00005010746,5.749598e-7,0.0001823472,0.002311077,0.01463109,0.002075411,0.01126596,0.0002926548],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900041,0.003543776,0.001585158,0.002931176,0.00004311435,0.0001508252,0.000005392399,0.00001087033,0.001725583],"genre_scores_gemma":[0.9952726,0.0009386466,0.003316596,0.0001113494,0.0002106797,0.00001682454,0.0000439084,0.00001626199,0.00007317368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1756212,"threshold_uncertainty_score":0.368014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06935331164926802,"score_gpt":0.3732606403747407,"score_spread":0.3039073287254727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}