{"id":"W3111363954","doi":"10.1111/xen.12669","title":"Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation","year":2020,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Health and Medical Research Council; Juvenile Diabetes Research Foundation International","keywords":"Transduction (biophysics); Inflammation; Biology; Viral vector; Islet; Signal transduction; Cancer research; Genetic enhancement; Cell biology; Immunology; Gene; Recombinant DNA; Endocrinology; Genetics; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002699765,0.0004856034,0.0002858712,0.0002481839,0.0002113789,0.0004888708,0.0002358188,0.0004145771,0.001093459],"category_scores_gemma":[0.0001464721,0.0001458819,0.0003394477,0.0002397504,0.0002118963,0.000246471,0.0002340151,0.0006538788,0.0005467497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000415764,"about_ca_system_score_gemma":0.0002589019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003968882,"about_ca_topic_score_gemma":0.0005120753,"domain_scores_codex":[0.999712,0.00003159816,0.00003720469,0.00007642953,0.00009507384,0.00004763465],"domain_scores_gemma":[0.9998304,0.00001899146,0.00005364254,0.00001782732,0.00003180993,0.00004738663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003678185,0.00002563544,0.0001190457,0.00001648262,0.000002690539,0.00002542474,0.000007396248,0.00005735682,0.9988909,0.00004227017,0.00002617638,0.0007496726],"study_design_scores_gemma":[0.00001898372,0.0003212088,0.001162627,0.000005493685,0.00002140437,0.0004031432,0.00001100595,0.001178629,0.9946961,0.00002210422,0.002152903,0.000006212084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970869,0.001015123,0.02489254,0.0001020905,0.00006888976,0.0002414917,0.0007070779,0.0002412788,0.001862508],"genre_scores_gemma":[0.9662209,0.0006868256,0.02799984,0.00008541869,0.00002203372,0.0002045704,0.001788621,0.00008822594,0.002903565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093459,"threshold_uncertainty_score":0.003657937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227971338078969,"score_gpt":0.2959810286582871,"score_spread":0.2731838948503902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}