{"id":"W3111363954","doi":"10.1111/xen.12669","title":"Selection of a novel AAV2/TNFAIP3 vector for local suppression of islet xenograft inflammation","year":2020,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Health and Medical Research Council; Juvenile Diabetes Research Foundation International","keywords":"Transduction (biophysics); Inflammation; Biology; Viral vector; Islet; Signal transduction; Cancer research; Genetic enhancement; Cell biology; Immunology; Gene; Recombinant DNA; Endocrinology; Genetics; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365966,0.00009843551,0.0001312047,0.00004567807,0.00003732595,0.000005385999,0.0001005115,0.0001177074,0.00002043143],"category_scores_gemma":[0.00002964319,0.00009946462,0.0000772369,0.0001395766,0.00005013286,0.000009246543,0.00000881186,0.00005370576,0.000001275312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008689805,"about_ca_system_score_gemma":0.00007083628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000142367,"about_ca_topic_score_gemma":0.00005141776,"domain_scores_codex":[0.9991771,0.00004523219,0.0002639561,0.0002012724,0.0001770873,0.0001353461],"domain_scores_gemma":[0.9995307,0.00002429242,0.0001205614,0.00009539506,0.0001806691,0.00004839708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006057029,0.00004948929,0.0002167992,0.0003063077,0.00004519266,1.363414e-7,0.0003452949,0.003327743,0.9867703,0.00004125906,0.00009796294,0.002742543],"study_design_scores_gemma":[0.001684916,0.002557446,0.000475615,0.00003101639,0.00003082226,0.000001987848,0.00004155222,0.01070398,0.9840346,0.00001287352,0.0003309177,0.00009430345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7623036,0.00004312394,0.2368656,0.0002089121,0.00003197202,0.000357401,0.0001473598,0.000009571883,0.00003244107],"genre_scores_gemma":[0.9971524,0.00008021175,0.001710298,0.00005087318,0.0001480587,0.00003571581,0.0007896021,0.00001957083,0.00001319941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2351553,"threshold_uncertainty_score":0.4056049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0227971338078969,"score_gpt":0.2959810286582871,"score_spread":0.2731838948503902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}