{"id":"W3111421261","doi":"10.1038/s10038-020-00895-6","title":"Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease","year":2021,"lang":"en","type":"article","venue":"Journal of Human Genetics","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Centre for Global Health Research","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Terveyden ja hyvinvoinnin laitos; Novo Nordisk Fonden; Oulun Yliopisto; Akademiska Sjukhuset; Government of Western Australia; Hjärt-Lungfonden; Murdoch University; Socialdepartementet; National Institutes of Health; University of Notre Dame Australia; Women and Infants Research Foundation; ZonMw; Raine Medical Research Foundation; National Institute for Health and Care Research; Vetenskapsrådet; Australian Government; King's College London; Nierstichting; University of Notre Dame; British Heart Foundation; Scottish Government; Curtin University of Technology; European Commission; Uppsala Universitet; Erasmus Universiteit Rotterdam; Edith Cowan University; Icahn School of Medicine at Mount Sinai; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Wellcome","keywords":"Expression quantitative trait loci; Biology; Internal medicine; Endocrinology; Genome-wide association study; Quantitative trait locus; Single-nucleotide polymorphism; Locus (genetics); Vitamin D-binding protein; Genetics; Genotype; Medicine; Gene; Vitamin D and neurology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005242092,0.0004780033,0.0003767638,0.0004686134,0.0002397598,0.0005050309,0.0002540178,0.0004342315,0.002104901],"category_scores_gemma":[0.001758014,0.0002159667,0.0009341558,0.0005550491,0.0002472977,0.0001282296,0.000255963,0.0004396547,0.0001920842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155088,"about_ca_system_score_gemma":0.0001387156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00360161,"about_ca_topic_score_gemma":0.002818336,"domain_scores_codex":[0.9994346,0.0001577389,0.00003846056,0.0002597037,0.00006744677,0.00004197658],"domain_scores_gemma":[0.9993365,0.0002624537,0.0002017683,0.00008645831,0.0000432861,0.00006947677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009143074,0.0001396348,0.7539941,0.0004317702,0.005542926,0.003463035,0.0006032829,0.002181359,0.1861496,0.0006996442,0.001461941,0.03618963],"study_design_scores_gemma":[0.00007898342,0.0002247373,0.9913698,0.00002336897,0.0007444202,0.001536396,0.0000553195,0.001385084,0.003406329,0.0003681385,0.0007848189,0.00002259441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960259,0.001209689,0.001264241,0.00008880211,0.00003796674,0.000006611562,0.000866446,0.00004747399,0.0004527156],"genre_scores_gemma":[0.9982986,0.0002634662,0.0005995148,0.00006223459,0.00001771165,0.000008142626,0.0003498387,0.00002021988,0.0003802872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00360161,"threshold_uncertainty_score":0.007161319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990661043339113,"score_gpt":0.2618309504804472,"score_spread":0.2419243400470561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}