{"id":"W3111470079","doi":"10.3390/vaccines8040773","title":"Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases","year":2020,"lang":"en","type":"review","venue":"Vaccines","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Government of Canada; University of Saskatchewan","keywords":"GroEL; Biology; Immune system; Heat shock protein; Antigen; Virulence; HSP60; Chaperone (clinical); Microbiology; Organism; Cell biology; Intracellular; Immunogenicity; Intracellular parasite; Bacteria; Hsp70; Immunology; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002226325,0.0004091024,0.0008310424,0.0001267285,0.0001809308,0.0001220147,0.0003099034,0.0003638879,0.00003842026],"category_scores_gemma":[0.001238407,0.000338517,0.0002888909,0.0001527811,0.00004339236,0.00000565631,0.0003479594,0.000154435,0.0000111676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006575237,"about_ca_system_score_gemma":0.0007471058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001157459,"about_ca_topic_score_gemma":0.00001886789,"domain_scores_codex":[0.997991,0.0003380523,0.0003638638,0.0007294598,0.0001623529,0.0004153033],"domain_scores_gemma":[0.998983,0.0001304161,0.0001237615,0.0004248119,0.00007029904,0.0002676656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01268134,0.0004318163,0.0001740166,0.08542645,0.002223962,0.0002706131,0.0001399159,0.000001339171,0.04970361,0.0004845414,0.01518867,0.8332737],"study_design_scores_gemma":[0.0005261818,0.0006732399,0.00001389298,0.00148491,0.0001787188,0.00003166967,0.000027541,0.000002971464,0.001825818,0.00004681286,0.9948056,0.0003825923],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00205741,0.9921889,0.0007547956,0.0002412398,0.0001512781,0.003266633,0.001276141,0.00003052537,0.00003312992],"genre_scores_gemma":[0.000812349,0.9957134,0.0002312958,0.00002207837,0.001123266,0.0006313299,0.0008536819,0.0001116325,0.00050095],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979617,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100490506964368,"score_gpt":0.3703125246045856,"score_spread":0.2602634739081487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}