{"id":"W3111482730","doi":"10.1093/carcin/bgaa132","title":"Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University; Population Health Research Institute; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Else Kröner-Fresenius-Stiftung; National Institute of Diabetes and Digestive and Kidney Diseases; Alfried Krupp von Bohlen und Halbach-Stiftung; Johns Hopkins University; University of Texas MD Anderson Cancer Center; Roswell Park Cancer Institute","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Insulin-like growth factor; SNP; Barrett's esophagus; Genetic association; Biology; Oncology; Adenocarcinoma; Copy-number variation; Genetic variation; Internal medicine; Medicine; Genotype; Cancer; Bioinformatics; Genetics; Gene; Receptor; Growth factor; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008533384,0.0003197698,0.0003307005,0.0006748738,0.0002227279,0.0004321124,0.0002301172,0.0003424315,0.001526798],"category_scores_gemma":[0.003275323,0.0002581762,0.0006604733,0.001016987,0.0002586833,0.0001545851,0.0003587395,0.0004295451,0.0001043486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049354,"about_ca_system_score_gemma":0.0001768247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005156763,"about_ca_topic_score_gemma":0.005675699,"domain_scores_codex":[0.9994395,0.0002109145,0.00004185167,0.000174279,0.00008382368,0.00004960396],"domain_scores_gemma":[0.9988895,0.0004751339,0.0003095523,0.0001293789,0.00006577857,0.0001307048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009592126,0.0000226026,0.9896497,0.00003089996,0.0007726882,0.0001547471,0.00004910332,0.0003799341,0.003519502,0.00006544933,0.0001030195,0.004293216],"study_design_scores_gemma":[0.00002746059,0.00006699312,0.99813,0.000006300684,0.0002695781,0.0002828912,0.00001971725,0.0006941771,0.0002647061,0.00008905363,0.0001456395,0.00000349714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980212,0.0007422058,0.000648359,0.00005233285,0.000007310035,0.00000501932,0.000269226,0.0000151312,0.000239146],"genre_scores_gemma":[0.9989969,0.0001613346,0.0004902765,0.00001285993,0.000006546818,0.000003286802,0.0002115578,0.00000469054,0.0001125939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005156763,"threshold_uncertainty_score":0.01025349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02524694671492739,"score_gpt":0.2565640989979797,"score_spread":0.2313171522830523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}