{"id":"W3111482730","doi":"10.1093/carcin/bgaa132","title":"Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma","year":2020,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McMaster University; Population Health Research Institute; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Else Kröner-Fresenius-Stiftung; National Institute of Diabetes and Digestive and Kidney Diseases; Alfried Krupp von Bohlen und Halbach-Stiftung; Johns Hopkins University; University of Texas MD Anderson Cancer Center; Roswell Park Cancer Institute","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Insulin-like growth factor; SNP; Barrett's esophagus; Genetic association; Biology; Oncology; Adenocarcinoma; Copy-number variation; Genetic variation; Internal medicine; Medicine; Genotype; Cancer; Bioinformatics; Genetics; Gene; Receptor; Growth factor; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480545,0.0002007439,0.000382746,0.0001092666,0.00007856398,0.00002162375,0.0001087382,0.00009045568,0.0000415212],"category_scores_gemma":[0.0002405535,0.0001379803,0.00007590728,0.0003460577,0.0001124632,0.00007862897,0.00007138934,0.0002112824,0.000004707806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000574284,"about_ca_system_score_gemma":0.0001337552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990407,"about_ca_topic_score_gemma":0.00003587075,"domain_scores_codex":[0.9984246,0.0002221055,0.0003050286,0.0003893111,0.0003929794,0.0002659471],"domain_scores_gemma":[0.9990667,0.0002185092,0.0001016523,0.0002336933,0.0001062795,0.0002731635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000423488,0.0000830908,0.9919909,0.0002258654,0.0001023978,0.000335311,0.00345716,0.000001554847,0.0003589075,0.0001332725,0.00003182414,0.00285618],"study_design_scores_gemma":[0.002764456,0.0008947458,0.9885233,0.00001965002,0.0001376842,0.00004113818,0.0001600004,0.0003090184,0.006966736,0.00008709203,0.00000447641,0.00009168088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.835288,0.1628443,0.00004939051,0.001059111,0.00002812218,0.0005579095,0.0001380793,0.0000180526,0.00001694875],"genre_scores_gemma":[0.9970384,0.001989409,0.000217718,0.0004903267,0.000154692,0.00005062526,0.00002244916,0.00002289292,0.00001346725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1617504,"threshold_uncertainty_score":0.5626674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02524694671492739,"score_gpt":0.2565640989979797,"score_spread":0.2313171522830523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}