{"id":"W3111494345","doi":"10.1016/s2152-2650(20)30973-3","title":"MDS-179: Clinical Benefit of Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes (LR-MDS) and High Transfusion Burden (HTB) in the Phase 3 MEDALIST Study","year":2020,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Anemia; Placebo; Myelodysplastic syndromes; Internal medicine; Population; Clinical trial; Refractory (planetary science); Surgery; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008581423,0.0009874612,0.00142339,0.0002389895,0.0002949465,0.001218041,0.0006533988,0.0007338505,0.003584796],"category_scores_gemma":[0.0006403057,0.000315145,0.001520556,0.0002754506,0.0006168205,0.000774169,0.0003389347,0.002506668,0.0007928805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007791515,"about_ca_system_score_gemma":0.001009082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007305918,"about_ca_topic_score_gemma":0.003148841,"domain_scores_codex":[0.9997537,0.0001054852,0.00001206153,0.00003827412,0.00003305813,0.00005759395],"domain_scores_gemma":[0.9997086,0.00004817572,0.0000667504,0.00002034245,0.00001496584,0.0001410832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7614444,0.01166462,0.01638995,0.001235725,0.003408088,0.0003325676,0.0001981328,0.004089596,0.02918768,0.0008528329,0.01524479,0.1559516],"study_design_scores_gemma":[0.7127048,0.1935238,0.06896576,0.0001240089,0.002394934,0.0007887089,0.0001445817,0.003304515,0.005498394,0.001197756,0.01123893,0.0001137562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892235,0.004356183,0.0002301476,0.001021903,0.0001692165,0.0003661163,0.001583358,0.0001099294,0.002939647],"genre_scores_gemma":[0.9901946,0.001924198,0.0006234414,0.001168483,0.0002160644,0.0002942786,0.003060051,0.00002854693,0.00249039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003584796,"threshold_uncertainty_score":0.01199234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03284904733416601,"score_gpt":0.3388579974242956,"score_spread":0.3060089500901296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}