{"id":"W3111507415","doi":"10.4049/jimmunol.2000576","title":"Sex-Biased Aging Effects on Ig Somatic Hypermutation Targeting","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; Broad Institute; Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Yale University","keywords":"Somatic hypermutation; Biology; DNA repair; Genetics; Somatic cell; DNA damage; Mutation; Phenotype; Gene; DNA; Antibody; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254561,0.000244692,0.0001843768,0.0005318226,0.0001005318,0.0001594608,0.00007826499,0.0001626066,0.001949983],"category_scores_gemma":[0.0003346966,0.00009106618,0.0001555534,0.0001600622,0.0001340507,0.000123998,0.0001745755,0.0001298541,0.0002116418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005296951,"about_ca_system_score_gemma":0.00005411224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001844763,"about_ca_topic_score_gemma":0.0002250834,"domain_scores_codex":[0.9998562,0.00003334495,0.00001492374,0.00004416924,0.00002410163,0.00002719821],"domain_scores_gemma":[0.9996742,0.00006793898,0.0001358099,0.00003223092,0.00003001096,0.0000597051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009366851,0.00004880511,0.1361224,0.00006516648,0.00005712892,0.0005770128,0.0001874771,0.00006249607,0.8467001,0.0000817894,0.0000701207,0.01509085],"study_design_scores_gemma":[0.000006950183,0.0006910141,0.9415556,0.000007117682,0.00005062771,0.002035018,0.00009115822,0.0001447955,0.0547282,0.00008399049,0.0005999162,0.000005684499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981495,0.000872355,0.0003312013,0.00001248029,0.000005515898,0.000003344732,0.0001384398,0.00001038407,0.0004768177],"genre_scores_gemma":[0.9991874,0.0001947851,0.0001621417,0.00001589281,0.000007195692,0.000003147699,0.0001086587,0.000004852485,0.0003159654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949983,"threshold_uncertainty_score":0.006523371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127040767471857,"score_gpt":0.2198671216034101,"score_spread":0.2085967139286915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}