{"id":"W3111507598","doi":"10.1186/s12916-020-01855-9","title":"Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study","year":2020,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; ZonMw; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; American Institute for Cancer Research; Kempe Foundation; Conseil Régional des Pays de la Loire; Matthias Lackas-Stiftung; Génome Québec; KWF Kankerbestrijding; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Pelotonia; Wellcome; Moffitt Cancer Center; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Cancer Research Foundation in Northern Sweden; Harvard T.H. Chan School of Public Health; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; University of Pittsburgh; World Cancer Research Fund International; McGill University; Association Anne de Bretagne Genetique; U.S. Department of Health and Human Services; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; American Cancer Society; University of South Florida","keywords":"Mendelian randomization; Medicine; Colorectal cancer; Body mass index; Odds ratio; Internal medicine; Oncology; Confidence interval; Genome-wide association study; Cancer; Waist–hip ratio; Waist; Endocrinology; Single-nucleotide polymorphism; Genetics; Genotype; Genetic variants; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01832055,0.001154233,0.001666886,0.0008126489,0.0005568197,0.0007581085,0.001035297,0.00108501,0.003293203],"category_scores_gemma":[0.0376405,0.0005925241,0.002008328,0.001316815,0.0007071242,0.000416103,0.0004948317,0.0006861521,0.0003024652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005016816,"about_ca_system_score_gemma":0.0008258876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003228824,"about_ca_topic_score_gemma":0.001728007,"domain_scores_codex":[0.9780208,0.01684425,0.0008962526,0.002619003,0.00128789,0.0003318995],"domain_scores_gemma":[0.9872103,0.006463049,0.00224932,0.003296326,0.0005263426,0.000254773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09080386,0.001535178,0.7466727,0.001467686,0.04993946,0.004250989,0.0008330441,0.005573155,0.01005864,0.009237955,0.009394368,0.07023293],"study_design_scores_gemma":[0.04893668,0.02405246,0.6749935,0.0007168244,0.06150939,0.02189713,0.0005421296,0.1077999,0.006116601,0.02791335,0.02506091,0.0004612628],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8817117,0.006362436,0.1033759,0.001019549,0.000520127,0.001835024,0.002610814,0.0005723113,0.001992084],"genre_scores_gemma":[0.9762145,0.0006889857,0.02031791,0.0003840613,0.0000924649,0.0009268999,0.0006602801,0.00006594582,0.0006489175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01832055,"threshold_uncertainty_score":0.09688944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069316681290087,"score_gpt":0.2910085011177471,"score_spread":0.2703153343048462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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