{"id":"W3111507598","doi":"10.1186/s12916-020-01855-9","title":"Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study","year":2020,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Elizabeth Blackwell Institute for Health Research, University of Bristol; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; ZonMw; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; American Institute for Cancer Research; Kempe Foundation; Conseil Régional des Pays de la Loire; Matthias Lackas-Stiftung; Génome Québec; KWF Kankerbestrijding; Wageningen University and Research; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Pelotonia; Wellcome; Moffitt Cancer Center; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Cancer Research Foundation in Northern Sweden; Harvard T.H. Chan School of Public Health; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; University of Pittsburgh; World Cancer Research Fund International; McGill University; Association Anne de Bretagne Genetique; U.S. Department of Health and Human Services; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; American Cancer Society; University of South Florida","keywords":"Mendelian randomization; Medicine; Colorectal cancer; Body mass index; Odds ratio; Internal medicine; Oncology; Confidence interval; Genome-wide association study; Cancer; Waist–hip ratio; Waist; Endocrinology; Single-nucleotide polymorphism; Genetics; Genotype; Genetic variants; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004498699,0.0001066047,0.0002611071,0.00002081101,0.00007868056,0.00000431232,0.00007580033,0.00007343861,0.00005615836],"category_scores_gemma":[0.001004012,0.00008110236,0.00002799525,0.0000906197,0.00005914852,0.000001462438,0.00006778331,0.00006321313,0.00000267726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005999769,"about_ca_system_score_gemma":0.00004203253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000340362,"about_ca_topic_score_gemma":0.0004952695,"domain_scores_codex":[0.9990031,0.0002603804,0.0002298532,0.0002843047,0.0000849912,0.0001374073],"domain_scores_gemma":[0.9995467,0.00004898266,0.0001204189,0.00009851986,0.00006382647,0.0001215177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002765895,0.00003761491,0.9580685,0.000009450957,0.0001414844,5.865584e-7,0.0004879254,0.0001759807,0.03472733,0.00001464804,0.004508215,0.001551695],"study_design_scores_gemma":[0.0109397,0.001384787,0.9720132,0.000008635744,0.0004669705,0.000003832035,0.0008747799,0.002530046,0.002952361,0.00006491933,0.008551368,0.0002094125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879267,0.00517812,0.004854574,0.001262406,0.0001184408,0.0003680466,0.00001704819,0.00001109021,0.0002636379],"genre_scores_gemma":[0.9966866,0.001188889,0.0006650617,0.0006912291,0.0005573758,0.00004454158,0.00006616264,0.00001030967,0.00008979538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03177497,"threshold_uncertainty_score":0.3307258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069316681290087,"score_gpt":0.2910085011177471,"score_spread":0.2703153343048462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}