{"id":"W3111592258","doi":"10.1093/neuonc/noaa222.015","title":"ATRT-16. MODELLING ATRT THROUGH SWI/SNF COMPLEX DEFICIENCY IN GENETICALLY-ENGINEERED MOUSE MODELS","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"SMARCB1; Atypical teratoid rhabdoid tumor; Biology; Embryonic stem cell; Stem cell; Cancer research; Progenitor cell; Neural stem cell; Cell biology; Genetics; Medulloblastoma; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008490292,0.001248117,0.0005570618,0.002504877,0.0004313048,0.0007661343,0.0008806667,0.001450544,0.004785135],"category_scores_gemma":[0.0003222143,0.0005871005,0.0009413594,0.0006689108,0.000953346,0.0005509108,0.0006076206,0.001696309,0.001739681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007468029,"about_ca_system_score_gemma":0.0004576821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008012246,"about_ca_topic_score_gemma":0.001462728,"domain_scores_codex":[0.9992932,0.0001074274,0.0001217803,0.0001854217,0.0001851687,0.0001070511],"domain_scores_gemma":[0.9993881,0.00006906231,0.0002817416,0.00006284801,0.00003836952,0.0001598321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003167434,0.0002547769,0.0003872916,0.00009703847,0.00002443066,0.000520421,0.00005609818,0.0006400143,0.9946255,0.0008742533,0.0002142232,0.001989234],"study_design_scores_gemma":[0.0002562139,0.002180831,0.002895394,0.00006151574,0.0001090139,0.00252301,0.00009346312,0.005788649,0.9719149,0.0003287509,0.01382297,0.00002537694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608822,0.001731876,0.02365629,0.0004334855,0.0001874174,0.001069253,0.005973144,0.000920347,0.005146091],"genre_scores_gemma":[0.9453137,0.002448083,0.02495439,0.0001868357,0.00003912138,0.002034222,0.004735029,0.0004760613,0.01981252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004785135,"threshold_uncertainty_score":0.0160079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05896338902273719,"score_gpt":0.2888073450202462,"score_spread":0.229843955997509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}