{"id":"W3111625461","doi":"10.1002/alz.041193","title":"Whole brain generative model identifies neurotransmitter alterations underlying Alzheimer's disease progression","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Neuroimaging; Neuroscience; Psychology; Alzheimer's disease; Functional neuroimaging; Neurotransmitter; Biology; Disease; Medicine; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001719709,0.001046756,0.0007996179,0.0010891,0.0002967824,0.0009902172,0.001243996,0.001482912,0.002834619],"category_scores_gemma":[0.003219743,0.0007109454,0.001903283,0.0004897346,0.0007815537,0.0006382175,0.0007453536,0.001977404,0.0005575779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126954,"about_ca_system_score_gemma":0.0007491351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01477435,"about_ca_topic_score_gemma":0.01825093,"domain_scores_codex":[0.9997252,0.00009807504,0.000008326843,0.0001079449,0.0000201209,0.00004034353],"domain_scores_gemma":[0.9985685,0.001102255,0.00009445783,0.00009445513,0.00008168596,0.00005861084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002837796,0.0001077145,0.01209583,0.00005289567,0.0002569252,0.0002011219,0.0001475487,0.9478073,0.002578271,0.007227924,0.002278054,0.0269627],"study_design_scores_gemma":[0.000008848653,0.00001286631,0.001300587,0.000006329965,0.00002438217,0.00003454691,0.000005145273,0.994984,0.0001880722,0.003272301,0.0001554078,0.000007412331],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4702971,0.001111735,0.5206909,0.001727993,0.0001207431,0.0001075163,0.001878983,0.001574249,0.002490787],"genre_scores_gemma":[0.9667376,0.0002957943,0.02687435,0.0002071541,0.00006265247,0.0001248205,0.00169795,0.0001337989,0.003865914],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01477435,"threshold_uncertainty_score":0.02937669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1287062056440584,"score_gpt":0.3314264570408622,"score_spread":0.2027202513968038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}