{"id":"W3111625486","doi":"10.1101/2020.12.04.412197","title":"Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"X-inactivation; Biology; Gene; X chromosome; Genetics; Epigenetics; DNA methylation; CTCF; Skewed X-inactivation; Y chromosome; Chromosome; Bonobo; Enhancer; Gene expression; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004133167,0.0001332321,0.0002044319,0.0008275727,0.0002661361,0.0003201694,0.0002037789,0.0002555448,0.002016211],"category_scores_gemma":[0.0005232714,0.0001001264,0.0001934366,0.0005286466,0.000341636,0.0002041167,0.0005634658,0.0002140536,0.0002076691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322961,"about_ca_system_score_gemma":0.0000883265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006921392,"about_ca_topic_score_gemma":0.001546604,"domain_scores_codex":[0.9996848,0.00004403298,0.00002582382,0.0001498579,0.00005263097,0.00004277786],"domain_scores_gemma":[0.9994266,0.0001655959,0.000210235,0.00006238833,0.00007732298,0.00005783845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002453357,0.00002174893,0.1909737,0.0002390559,0.0001883851,0.0001475647,0.0004355846,0.0001223642,0.8004773,0.0001719603,0.00008406932,0.006892849],"study_design_scores_gemma":[0.000001794085,0.0001191344,0.9726053,0.00001781036,0.00005826297,0.0004666777,0.0003090007,0.0002958242,0.02497905,0.0001324869,0.001009138,0.000005584666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968776,0.0009868135,0.0008312982,0.0000169785,0.000003696815,0.000004854231,0.0003620852,0.00002091105,0.0008957375],"genre_scores_gemma":[0.9985681,0.0001417318,0.0005136605,0.00003650685,0.000002628125,0.00000938443,0.0004289951,0.0000109978,0.000287945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002016211,"threshold_uncertainty_score":0.006744921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161561018433893,"score_gpt":0.2364347583253831,"score_spread":0.2202786564819938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}