{"id":"W3111656069","doi":"10.1126/sciadv.abb0385","title":"Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Diphtheria toxin; Internalization; Toxin; Enzyme; Receptor; Diphtheria; Chemistry; Endocytosis; Receptor-mediated endocytosis; Biochemistry; Microbiology; Biology; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829573,0.0004316031,0.0004454504,0.0002893934,0.00015559,0.0005197374,0.0002709097,0.0006083521,0.0008726399],"category_scores_gemma":[0.0001535218,0.000181551,0.0003117595,0.0001456928,0.0004040676,0.0004529417,0.0004802132,0.0007583505,0.0003396779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006408414,"about_ca_system_score_gemma":0.0003344517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006382117,"about_ca_topic_score_gemma":0.0007822817,"domain_scores_codex":[0.9997948,0.00003707656,0.00001598075,0.00004219515,0.00005277659,0.00005723395],"domain_scores_gemma":[0.9998934,0.00002827157,0.0000358682,0.00001403945,0.000009880061,0.00001850425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002605432,0.00001322096,0.00004427951,0.0000213537,0.000002850274,0.00003856172,0.000009136565,0.00008387562,0.9987968,0.0002527159,0.00002371766,0.0006873495],"study_design_scores_gemma":[0.00001053484,0.0001395559,0.0003962474,0.00000314797,0.00001230059,0.0002386961,0.000006766877,0.000784812,0.9965918,0.00003639876,0.001776568,0.000003165331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658756,0.003170058,0.02670866,0.0005150795,0.0000538544,0.0001110411,0.0001871313,0.0002722485,0.003106367],"genre_scores_gemma":[0.9821523,0.002004776,0.01331204,0.00008412072,0.00001154638,0.00003829378,0.0001357928,0.00003456264,0.002226367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008726399,"threshold_uncertainty_score":0.004649639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287396910197369,"score_gpt":0.2752858300742517,"score_spread":0.252411860972278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}