{"id":"W3111656069","doi":"10.1126/sciadv.abb0385","title":"Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy","year":2020,"lang":"en","type":"article","venue":"Science Advances","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Diphtheria toxin; Internalization; Toxin; Enzyme; Receptor; Diphtheria; Chemistry; Endocytosis; Receptor-mediated endocytosis; Biochemistry; Microbiology; Biology; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004806191,0.0001207849,0.0001724256,0.00005193934,0.0003443384,0.00003327777,0.000609458,0.00003573933,0.0002247677],"category_scores_gemma":[0.0002524527,0.00007781027,0.0000572191,0.0003654853,0.000318873,0.0004229126,0.00009858147,0.00006824265,0.00003570277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002515842,"about_ca_system_score_gemma":0.00008101405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001590883,"about_ca_topic_score_gemma":0.000006967501,"domain_scores_codex":[0.9989496,0.00005706792,0.0002807966,0.0003428011,0.00008901924,0.0002806777],"domain_scores_gemma":[0.9993628,0.00008635672,0.000194009,0.0001968248,0.000134508,0.00002544599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003042911,0.00002638002,0.00006734806,0.00001013854,0.00001456397,4.278915e-8,0.00252418,0.00003829734,0.9667758,0.0009124805,0.000101053,0.02922536],"study_design_scores_gemma":[0.0004018488,0.0009635541,0.00005744331,0.00004497338,0.00000328672,6.037018e-7,0.002592031,0.00001396573,0.935951,0.0002363798,0.05963431,0.000100623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550774,0.004236171,0.03725605,0.001420103,0.0007546532,0.00108616,0.00002775883,0.00004427282,0.00009742507],"genre_scores_gemma":[0.9949114,0.0002679531,0.003408933,0.000873793,0.00005308222,0.0002115599,0.00000594435,0.00000955397,0.0002577609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05953325,"threshold_uncertainty_score":0.3173011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287396910197369,"score_gpt":0.2752858300742517,"score_spread":0.252411860972278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}