{"id":"W3111710464","doi":"10.1093/neuonc/noaa222.259","title":"GCT-41. RESPONSE-BASED RADIATION THERAPY IN PATIENTS WITH NEWLY DIAGNOSED CENTRAL NERVOUS SYSTEM LOCALIZED GERMINOMA: A CHILDREN’S ONCOLOGY GROUP (COG) PROSPECTIVE PHASE 2 CLINICAL TRIAL","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Cog; Carboplatin; Etoposide; Germinoma; Chemotherapy; Radiation therapy; Phases of clinical research; Internal medicine; Central nervous system; Surgery; Oncology; Gastroenterology; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005394132,0.000467875,0.001584826,0.0002457216,0.0001078262,0.00002813294,0.0001936393,0.0005266562,0.0000624813],"category_scores_gemma":[0.000916854,0.0003607246,0.0003064778,0.0005350093,0.0002253359,0.00009504727,0.00004564515,0.0006655779,0.00003646209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001363409,"about_ca_system_score_gemma":0.001305118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001188412,"about_ca_topic_score_gemma":0.00007290875,"domain_scores_codex":[0.9941245,0.002418098,0.001221895,0.001074387,0.0004375882,0.0007235398],"domain_scores_gemma":[0.9958094,0.002338828,0.0006322383,0.0004268099,0.0001587233,0.0006340499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4674889,0.01623719,0.4419218,0.0000186316,0.0002407606,0.002565072,0.0004816567,0.00005347738,0.0006491629,0.00002885245,0.0007671815,0.06954733],"study_design_scores_gemma":[0.4137532,0.1044796,0.4749946,0.00002656557,0.0002570738,0.00002573479,0.00004355528,0.0005593504,0.0004475827,0.000001568779,0.005220167,0.0001909673],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853768,0.0001604303,0.00006301796,0.00465933,0.0008589062,0.008548236,0.00006724475,0.0001840365,0.00008198413],"genre_scores_gemma":[0.9922819,0.00004730865,0.0002639901,0.005066377,0.0007205585,0.001301357,0.0002385184,0.00007898652,9.766316e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08824238,"threshold_uncertainty_score":0.9998845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02977931541336713,"score_gpt":0.3299005253535205,"score_spread":0.3001212099401533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}