{"id":"W3111739908","doi":"10.3389/fbioe.2020.537847","title":"The Microbiome and Alzheimer’s Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations","year":2020,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prebiotic; Synbiotics; Microbiome; Probiotic; Neuroinflammation; Disease; Gut flora; Gut microbiome; Gut–brain axis; Biology; Intestinal permeability; Bioinformatics; Immunology; Medicine; Inflammation; Neuroscience; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007448856,0.0007243741,0.001257232,0.001644274,0.0002468617,0.001218507,0.0005928,0.001280576,0.003003162],"category_scores_gemma":[0.0009251221,0.0002517402,0.0005172118,0.001544634,0.0004587694,0.001293022,0.0008463854,0.001695625,0.001049943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004991419,"about_ca_system_score_gemma":0.001010725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000906168,"about_ca_topic_score_gemma":0.001770827,"domain_scores_codex":[0.9998057,0.00004908576,0.00002956756,0.00003435275,0.00006437948,0.00001696108],"domain_scores_gemma":[0.9996319,0.0002291093,0.0000389141,0.00001016531,0.00006248678,0.00002739725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001296251,0.0000767285,0.0001610495,0.02214462,0.00009073693,0.0001782134,0.00008063501,0.0002290598,0.002379961,0.005502759,0.01331925,0.9557072],"study_design_scores_gemma":[0.00002443968,0.0001958224,0.001201729,0.008026588,0.0001492381,0.00117624,0.0001097487,0.000126367,0.0007458538,0.003678055,0.9845436,0.00002229672],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009377909,0.9990916,0.00005330022,0.0001982653,0.0001159876,0.000001727382,0.000006454173,0.000001918362,0.0004368461],"genre_scores_gemma":[0.0006387188,0.9986544,0.000114829,0.0001470203,0.000111832,0.000004271948,0.0000108937,9.147427e-7,0.0003170981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003003162,"threshold_uncertainty_score":0.01004654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960020977793984,"score_gpt":0.2490684944306636,"score_spread":0.2294682846527238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}