{"id":"W3111739908","doi":"10.3389/fbioe.2020.537847","title":"The Microbiome and Alzheimer’s Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations","year":2020,"lang":"en","type":"review","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prebiotic; Synbiotics; Microbiome; Probiotic; Neuroinflammation; Disease; Gut flora; Gut microbiome; Gut–brain axis; Biology; Intestinal permeability; Bioinformatics; Immunology; Medicine; Inflammation; Neuroscience; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074105,0.0003083288,0.0006133784,0.0002247084,0.0001323289,0.00003710591,0.0001404566,0.0005760899,1.362758e-7],"category_scores_gemma":[0.00009042808,0.0002426591,0.00006418304,0.0001909849,0.000531654,0.000005599709,0.0002561257,0.0002779129,2.154535e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001345813,"about_ca_system_score_gemma":0.00008206735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000490242,"about_ca_topic_score_gemma":0.000008917405,"domain_scores_codex":[0.9987646,0.00004059986,0.0003906465,0.0004733716,0.00003888348,0.0002919078],"domain_scores_gemma":[0.9994484,0.00003822761,0.0001384048,0.0002393274,0.00002057981,0.0001150804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003372509,0.00004004552,0.0002006588,0.004882813,0.0004536557,0.000009633602,0.00005045316,0.000005340876,0.005507125,0.0008210678,0.0005210609,0.9874744],"study_design_scores_gemma":[0.0004743861,0.0002986052,0.0009147974,0.001227662,0.0007874218,0.0001950021,0.00008921393,0.0006065831,0.0002792354,0.00009467338,0.9945098,0.0005226177],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001606158,0.9951346,0.001505516,0.000779012,0.0001924074,0.0006405978,0.0001148509,0.0000242024,0.000002691156],"genre_scores_gemma":[0.01363628,0.9811742,0.004971344,0.00001431698,0.00003819857,0.00001476211,0.000101693,0.00003155162,0.0000176286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9939888,"threshold_uncertainty_score":0.9895351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960020977793984,"score_gpt":0.2490684944306636,"score_spread":0.2294682846527238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}